Pleural amyloidosis does not present with specific imaging findings and is difficult to diagnose unless pleural biopsy is performed. However, distinguishing pleural amyloidosis from malignant disease is important and biopsy should be performed wherever possible to establish a treatment plan as early as possible.
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Background: Light-chain cardiac amyloidosis (AL-CA) is associated with structural and functional changes in the left atrium and left ventricle. This study aims to assess the value of the left atrioventricular coupling index (LACI) assessed by three-dimensional echocardiography (3DE) for predicting primary outcome in AL-CA.
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Article Synopsis
- Amyloidosis is a serious multi-organ disease increasingly relevant in cardiology, and chylothorax—an unusual fluid accumulation in the pleural cavity—has been reported in only a few cases linked to cardiac amyloidosis, all in AL type, with none in ATTR type.
- The case under discussion involves an 85-year-old man diagnosed with ATTR cardiac amyloidosis who developed chylothorax, indicated by elevated serum CA 125 levels, and unfortunately passed away shortly after due to an embolic stroke.
- More research is needed to understand how chylothorax develops in amyloidosis cases and to explore CA 125's potential role as a prognostic marker in ATTR amyloidosis.
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Pulmonary amyloidosis is an extremely rare disease, often detected incidentally because of its asymptomatic nature and potential to result in fatal outcomes. In this study, we aimed to present the clinical and radiological features of patients diagnosed with pulmonary amyloidosis by biopsy. This descriptive study included 21 patients with pathologically diagnosed pulmonary amyloidosis.
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