Background In Japan, effective educational methods to promote understanding of developmental disorders (DD) among young people have not been established, something that is necessary for an inclusive society. Aims This paper aimed to identify both the positive aspects and areas for improvement in a problem-solving program for middle and high school students on the topic of DD called inochi Gakusei Innovators Program (i-GIP). The study also sought to determine the changes in attitudes toward DD that occurred as a result of participating in the program. Method Semi-structured interviews were conducted online, with middle and high school students who participated in i-GIP, university students who helped manage the program, and cooperators with DD or their families. Inductive thematic analysis was conducted, and codes and themes were identified. Results Positive aspects of i-GIP included its project-based learning approach, raising awareness and understanding of developmental disorders, and the proactive attitude of the students. Areas for improvement in the program were identified, including program administration and addressing challenges related specifically to DD. Changes in attitudes and behavior toward DD were reported, along with improvements in interpersonal relationships. Conclusions and implications This study suggests that incorporating a project-based approach can be a useful manner to learn about DD among young people.
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http://dx.doi.org/10.7759/cureus.51679 | DOI Listing |
Front Pediatr
December 2024
Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, United States.
RHOBTB2 is a member of the Rho GTPases subfamily of signaling proteins, known tumor suppressors whose loss of function and decreased expression is associated with cancer onset. Beyond its cancer-related role, RHOBTB2 is implicated in rare neurodevelopmental disorders, specifically -related disorders, recognized in 2018 as a subtype of developmental and epileptic encephalopathies (DEE). Common symptoms of these disorders include early-onset epilepsy, severe intellectual disability, microcephaly, and movement disorders.
View Article and Find Full Text PDFJ Eat Disord
December 2024
School of Psychology and Public Health, La Trobe University, Melbourne, Australia.
Background: Biopsychosocial factors have been associated with body satisfaction/dissatisfaction and related body image concerns in adolescence; however, few studies have investigated these relationships in middle childhood, an important developmental phase for body satisfaction. This study investigated relationships between a range of biological (body mass index), psychological (child anxiety/depression, self-esteem, and self-oriented and socially prescribed perfectionism) and sociocultural (mother's body dissatisfaction and comments about child's appearance, father's body dissatisfaction and comments about child's appearance, peer teasing and child's media exposure) factors and body satisfaction cross-sectionally and longitudinally in a sample of 7- and 8-year-old children.
Methods: In this study, participants from the longitudinal Children's Body Image Development Study (in which children had been followed-up annually from 3 years old) were assessed by interview at 7 years old (Time 1; n = 293: girls = 167, boys = 126) and 8 years old (Time 2; n = 222; girls = 126, boys = 96) and their parents completed a questionnaire at each time point.
Ann Rehabil Med
December 2024
Division of Neurology and Developmental Neuroscience, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, United States.
Cerebral palsy (CP) is the most common motor disability in children, characterized by diverse clinical manifestations and often uncertain etiology, which has spurred increasing interest in genetic diagnostics. This review synthesizes findings from various studies to enhance understanding of CP's genetic underpinnings. The discussion is structured around five key areas: monogenic causes and copy number variants directly linked to CP, differential genetic disorders including atypical CP and mimics, ambiguous genetic influences, co-occurrence with other neurodevelopmental disorders, and polygenic risk factors.
View Article and Find Full Text PDFCurr Opin Cell Biol
December 2024
Department of Cell & Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, United States. Electronic address:
Mitochondria are dynamic organelles essential for cellular homeostasis, undergoing continuous fission and fusion processes that regulate their morphology, distribution, and function. Disruptions in these dynamics are linked to numerous diseases, including neurodegenerative disorders and cancer. Understanding these processes is vital for developing therapeutic strategies aimed at mitigating mitochondrial dysfunction.
View Article and Find Full Text PDFThis primigravid pregnant woman had a new diagnosis of primary biliary cholangitis (PBC) that was treated with a combination of ursodeoxycholic acid (UDCA) and bezafibrate. Pregnancy may unmask underlying chronic hepatic disorders in susceptible women and, in some cases, the associated abnormalities of liver function or increased serum bile acids (hypercholanaemia) can result in significant fetal and maternal risk. Maternal pruritus, with associated sleep deprivation, may cause considerable distress.
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