Male infertility is a global health concern. However, its underlying pathophysiology remains unclear. Taste receptor type 1 member 3 (TAS1R3) is highly expressed in the testes, indicating its potential involvement in male fertility. Using wild-type and knockout (KO) mice, we investigated whether TAS1R3 modulates male reproductive function. KO mice exhibited reduced male fertility compared to WT mice, with fewer live pups per litter and a delayed first litter. Testicular transcriptome analysis indicated suppressed PKA/CREB/StAR signaling-mediated testosterone synthesis in KO mice. single-cell RNA sequencing revealed considerably higher expression in Leydig cells than in other testicular cell subtypes. An study validated that knockdown downregulated the expression of and steroidogenic genes in Leydig cells. Our results suggest that testicular TAS1R3 is intricately involved in male reproduction via the PKA/CREB/StAR signaling pathway, highlighting its potential as a promising target for addressing male infertility.
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| http://dx.doi.org/10.1016/j.heliyon.2024.e24577 | DOI Listing |
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