Based on the major components in the leaves, the ashwagandha has been found to exist in several chemotypic forms in India. From the leaves of various accessions of , which were maintained in our institute, three new steroids namely, 4-acetoxy-20β-hydroxy-1-oxo-witha-2,5,24-trienolide (), 24,25-dihydro-14α-hydroxy withanolide D (), 5α,6β,17α,27-tetrahydroxy-1-oxo-witha-2,24-dienolide () together with thirteen known withanolides were identified by spectroscopic methods. From the roots and stem of one accession and leaves of another, a new alkyl ester glucoside () has also been isolated. The new withanolides and have been tentatively named as withanolide 135 A, withanolide 135B and withanolide 108, respectively.
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http://dx.doi.org/10.1080/10286020.2024.2308184 | DOI Listing |
BMC Plant Biol
November 2024
School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China.
Background: DNA methylation is a crucial epigenetic mechanism that regulates gene expression during plant growth and development. However, the role of DNA methylation in regulating the organ-specific functions of the invasive weed Mikania micrantha remains unknown.
Results: Here, we generated DNA methylation profiles for M.
Int J Mol Sci
November 2024
State Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, Northeast Forestry University, Harbin 150040, China.
'Purple Rain' is characterized by its purple leaves and has ornamental applications. A green mutant line NL, which was mutated by line NZ of 'Purple Rain' during tissue culture, shows green leaves instead of the typical purple color of 'Purple Rain'. This study quantified the leaf color traits of NL and a normal 'Purple Rain' line NZ, and uncovered differentially expressed genes involved in flavonoid biosynthesis pathway genes in NL through RNA-Seq analysis.
View Article and Find Full Text PDFMol Syst Biol
December 2024
Genomic Epidemiology branch, International Agency for Research on Cancer/World Health Organization (IARC/WHO), Lyon, 69366, France.
Biological mechanisms related to cancer development can leave distinct molecular fingerprints in tumours. By leveraging multi-omics and epidemiological information, we can unveil relationships between carcinogenesis processes that would otherwise remain hidden. Our integrative analysis of DNA methylome, transcriptome, and somatic mutation profiles of kidney tumours linked ageing, epithelial-mesenchymal transition (EMT), and xenobiotic metabolism to kidney carcinogenesis.
View Article and Find Full Text PDFSci Adv
November 2024
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
We present a versatile nickel-electrocatalytic deaminative cross-coupling platform for the efficient construction of C(sp)-C(sp) and C(sp)-C(sp) bonds from readily available alkyl bistriflimides. This methodology involves the assembly of two leaving groups on alkyl amines to form alkyl bistriflimides, followed by their effective coupling with a wide range of alkyl halides, alkyl pseudohalides, aryl halides, and alkenyl halides under electrochemical reductive conditions. Moreover, the successful application of electrochemical reductive relay cross-coupling and transition metal-free cross-electrophile coupling further demonstrates the versatility of alkyl bistriflimides as valuable building blocks in organic synthesis.
View Article and Find Full Text PDFEur J Med Chem
January 2025
Department of Organic Chemistry, Faculty of Chemistry, University of Seville, E-41012, Seville, Spain. Electronic address:
Invariant natural killer T (iNKT) cells are a subset of innate T cells displaying powerful immunomodulatory functions. Despite extensive preclinical research on the use of iNKT agonist and antagonist for various diseases, translating these findings into successful clinical applications has proven challenging, leaving no approved treatments to date. Efforts to optimize therapeutic outcomes by developing alternative glycolipids to α-galactosylceramide (α-GalCer or KRN7000), the prototypical iNKT antigen, have shown improved preclinical results.
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