We propose a friendly amendment to integrative experiment design (IED), adversarial-collaboration IED, that incentivizes research teams from competing theoretical perspectives to identify zones of the design space where they possess an explanatory edge. This amendment is especially critical in debates that have high policy stakes and carry a strong normative-political charge that might otherwise prevent free exchange of ideas.
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Behav Brain Sci
February 2024
The Wharton School, University of Pennsylvania, Philadelphia, PA,
We propose a friendly amendment to integrative experiment design (IED), adversarial-collaboration IED, that incentivizes research teams from competing theoretical perspectives to identify zones of the design space where they possess an explanatory edge. This amendment is especially critical in debates that have high policy stakes and carry a strong normative-political charge that might otherwise prevent free exchange of ideas.
View Article and Find Full Text PDFCase-Informed Learning in Medical Education: A Call for Ontological Fidelity.
Perspect Med Educ
April 2023
Department of Continuing Professional Development and Medical Education, Dalhousie University, Halifax, Nova Scotia, Canada.
Case-informed learning is an umbrella term we use to classify pedagogical approaches that use text-based cases for learning. Examples include Problem-Based, Case-Based, and Team-Based approaches, amongst others. We contend that the cases at the heart of case-informed learning are philosophical artefacts that reveal traditional positivist orientations of medical education and medicine, more broadly, through their centering scientific knowledge and objective fact.
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J Med Chem
February 2002
Institute of Pharmaceutical Chemistry, Heinrich-Heine-Universität, Universitätsstrasse 1, D-40225 Düsseldorf, Germany.
We synthesized K(ATP)-channel openers (KCOs) composed of the 4-pyridonechromene moiety of bimakalim (1) and a variety of sulfonyl-containing 6-substituents 4-29. Dilator potencies were measured in rat aorta and trachea. In both test systems the KCOs exhibit potency ranges of roughly 3 log units.
View Article and Find Full Text PDFPharmacological agents for the treatment of urinary incontinence due to overactive bladder.
Expert Opin Investig Drugs
January 2001
Division of Urology, University of Pennsylvania Health System, First Floor Rhoads Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Although the exact aetiology of overactive bladder is unknown to date, pharmacological therapy has been targeted to both the central and peripheral nervous systems. Potential CNS targets include GABA, opioid, serotonin (5-HT), dopamine and glutaminergic receptors as well as the alpha-adrenoceptors. Potential PNS targets include muscarinic receptors, calcium and potassium channels and alpha- and beta-adrenergic receptors.
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