Almaatouq et al. propose an "integrative approach" to increase the generalisability and commensurability of experiments. Yet their metascientific approach has one glaring omission (and misinterpretation of) - the role of sample diversity in generalisability. In this commentary, we challenge false notions of subsumed duality between contexts, population, and diversity, and propose modifications to their design space to accommodate sample diversity.
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http://dx.doi.org/10.1017/S0140525X23002212 | DOI Listing |
Alzheimers Dement
December 2024
Loma Linda University Health, Loma Linda, CA, USA.
Background: Only about 50% of the variance in cognitive decline occurring during Alzheimer's pathogenesis is attributable to standard AD biomarkers (cerebrocortical Aβ, pathological tau, and atrophy) (Tosun et al., Alzheimer's Dement. 18: 1370, 2022).
View Article and Find Full Text PDFBackground: To improve clinical translatability of non-clinical in-vivo Alzheimer's disease (AD) models, a humanized APP knock-in mouse model (APP) was recently created (Xia, D. et al., 2022).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
Background: Prior research has demonstrated the positive association between social support and cognition. Specifically, greater social support has been linked with improved cognitive performance and reduced risk of dementia. In particular, emotional support has been identified as a key dimension in the relationship between social support and cognition.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
7072 mulago hill, Kampala, Uganda.
Background: In Uganda, caregivers of Alzheimer's disease and related dementias (ADRD) face complex challenges, often lacking specialized skills for effective caregiving. Despite the growing prevalence of ADRD in the country, there's a significant literature gap on caregiver selection and obstacles faced in urban and rural areas. This study aims to provide insights into the experiences of Ugandan caregivers, enhancing understanding of ADRD caregiving.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Medical College of Georgia, Augusta, GA, USA.
Background: Alzheimer's disease poses significant global health challenges, particularly as people increasingly turn to online platforms for health information in the digital era. Given the intricate nature of Alzheimer's, it is imperative to evaluate the readability of online content. This study aims to assess the readability of information related to Alzheimer's disease on reputable health websites.
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