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[Efficacy of brolucizumab in the treatment of retinal pathologies: a review of post-marketing studies].
Vestn Oftalmol
November 2024
S.M. Kirov Military Medical Academy, Saint Petersburg, Russia.
Brolucizumab, an angiogenesis inhibitor, is a single-chain fragment of a humanized antibody used to treat neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME). Although registration studies are the primary source of information on the new drug, post-marketing studies allow for further exploration and expansion of previous knowledge about its effectiveness, safety, and dosing regimens. This study summarizes the experience with brolucizumab from real-world clinical practice studies.
View Article and Find Full Text PDFUnexpected peritoneal metastases diagnosed at the time of primary colon cancer resection: controversies regarding options for management.
J Gastrointest Oncol
October 2024
Department of Colorectal Surgery, Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, FL, USA.
Peritoneal metastases synchronously occurring in the patient with primary colon cancer causes that patient to be at high risk for subsequent disease progression within the abdomen and pelvis. If peritoneal metastases are preoperatively diagnosed, patients are likely to be treated with neoadjuvant chemotherapy with or without biological therapy prior to cytoreductive surgery (CRS). However, if one only considers patients with peritoneal metastases unexpectedly identified at the time of primary colon cancer resection, the optimal management strategy is neither standardized nor evidence based.
View Article and Find Full Text PDFReview on classification of polypoidal choroidal vasculopathy.
Int Ophthalmol
November 2024
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Background: Polypoidal choroidal vasculopathy (PCV) is a complex vascular disorder characterized by a branching neovascular network with polypoidal lesions at its termini. Despite extensive research, the etiology and pathogenesis of PCV remain inadequately understood, and the condition exhibits significant clinical and pathological heterogeneity. In recent years, numerous studies have identified potential subtypes within PCV and proposed various classification schemes.
View Article and Find Full Text PDFPrimary lymphoma of mucosa associated lymphoid tissue (MALT lymphoma) in the urinary bladder mimicking recurrent urinary tract infection: a case report and literature review.
BMC Urol
October 2024
Division of Urology, Department of Surgery, Changhua Christian Hospital, Changhua City, Changhua County, Taiwan.
Article Synopsis
- A 79-year-old woman was diagnosed with primary lymphoma of mucosa-associated lymphoid tissue (MALT) in her urinary bladder after experiencing urinary issues and recurrent infections.
- Imaging tests showed a bladder tumor, which was surgically removed and confirmed to be MALT lymphoma.
- The patient received follow-up radiotherapy for residual tumors and was disease-free nine months later; however, distinguishing bladder lymphoma from other cancer types can be challenging, and more research is needed for optimal treatment strategies.
S100 and CD34 positive spindle cell tumors of the uterine cervix with EGFR mutation: a hitherto unrecognized neoplasm phenotypically and epigenetically overlapping with "NTRK-rearranged spindle cell neoplasms" of the uterus.
Virchows Arch
October 2024
Bioptical Laboratory, Ltd., Pilsen, Czech Republic.
NTRK-rearranged spindle cell neoplasm represents an emerging entity included in the latest 5th edition of WHO classification of both soft tissue and female genital tumors. By immunohistochemistry, they are commonly positive for CD34, S100 protein, and CD30 and typically harbor fusions of kinase genes such as NTRK1/2/3, RET, and BRAF. In the gynecological tract, they typically affect the uterine cervix or uterine body.
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