Purpose: To determine the effects of topical tranexamic acid (TXA) administration on tendon adhesions, shoulder range of motion (ROM), and tendon healing in an acute rotator cuff repair rat model.
Methods: A total of 20 Sprague Dawley rats were used. Tendon adhesion, ROM, and biomechanical and histological analysis of tendon-bone healing was conducted at 3 and 6 weeks after surgery. The rats underwent rotator cuff repair surgery on both shoulders and were administered TXA via subacromial injections. The tendon adhesion was evaluated macroscopically and histologically. Biomechanical tendon healing was measured using a universal testing machine, and histological analysis was quantified by H&E, Masson's trichrome, and picrosirius red staining.
Results: At 3 weeks after surgery, the adhesion score was significantly lower in the TXA group (2.10 ± 0.32) than in the control group (2.70 ± 0.48) (P = .005), but there was no significant difference between the 2 groups at 6 weeks. Regarding ROM, compared with the control group, the TXA group showed significantly higher external rotation (36.35° ± 4.52° vs 28.42° ± 4.66°, P < .001) and internal rotation (45.35° ± 9.36° vs 38.94° ± 5.23°, P = .013) 3 weeks after surgery. However, at 6 weeks, there were no significant differences in external and internal rotation between the 2 groups. In the biomechanical analysis, no significant differences in gross examination (3 weeks, P = .175, 6 weeks, P = .295), load to failure (3 weeks, P = .117, 6 weeks, P = .295), or ultimate stress (3 weeks, P = .602, 6 weeks, P = .917) were noted between the 2 groups 3 and 6 weeks after surgery. In the histological analysis of tendon healing, no significant differences in the total score (3 weeks, P = .323, 6 weeks, P = .572) were found between the 2 groups 3 and 6 weeks after surgery.
Conclusions: Topical TXA administration showed a beneficial effect in reducing tendon adhesions and improving ROM 3 weeks postoperatively and had no effect at 6 weeks. This suggests that additional intervention with TXA may be useful in achieving long-term improvement in shoulder stiffness. Additionally, TXA may increase tissue ground substance accumulation in the late postoperative period but does not adversely affect tendon-bone interface healing.
Clinical Relevance: The use of TXA after rotator cuff repair has no effect on tendon-bone interface healing in clinical practice and can improve shoulder stiffness in the early postoperative period. Additional research on the long-term effects is needed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.arthro.2024.01.027 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fabrication and characterization of lactoperoxidase coated the modified graphene oxide-based nanocomposite for medical applications.
Int J Biol Macromol
December 2024
Institute of Biological and Chemical Systems - Functional Molecular Systems (IBCS-FMS), Kaiserstrasse 12, 76131 Karlsruhe, Germany. Electronic address:
Article Synopsis
- This study focuses on creating a new nanocomposite (GO-PAA-Cu-LP) for medical uses through a multi-step synthesis involving graphene oxide and polyacrylic acid.
- The research includes a variety of characterization techniques to analyze the nanocomposite, demonstrating that it retains about 73% of its reactivity even after 9 weeks of storage at low temperatures.
- The findings show that the modified GO-PAA-Cu-LP has enhanced selectivity against cancer cells, promoting apoptosis and cell cycle arrest compared to standard composites and lactoperoxidase alone.
Inhalation exposure to cross-linked polyacrylic acid induces pulmonary disorders.
Toxicology
January 2025
Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka 807-8555, Japan. Electronic address:
Article Synopsis
- - Organic polymers like cross-linked polyacrylic acid (CL-PAA), widely used in various products, have been linked to severe lung diseases, prompting research into the effects of inhalation exposure rather than just instillation.
- - The study involved two exposure durations (5 days and 13 weeks) with male F344 rats, revealing that both short- and long-term exposure to CL-PAA caused significant inflammation, increased neutrophil activity, and lung fibrosis, especially at higher concentrations.
- - Administration of the antioxidant N-acetylcysteine (NAC) reduced the adverse effects of CL-PAA, decreasing inflammation markers and improving overall lung tissue health, indicating it may offer a protective benefit against oxidative stress-induced
Effect of Surface Treatments on Shear-bond Strength of Glass Ionomer Cements to Silver Diamine Fluoride-treated Simulated Carious Dentin.
Oper Dent
November 2024
Adrian Ujin Yap, PhD, MSc, BDS, Grad Dip Psychotherapy, adjunct professor, Faculty of Dentistry, University Malaya, Kuala Lumpur, Malaysia; senior consultant, Division of Dentistry, and director of research, Ng Teng Fong General Hospital and Faculty of Dentistry, National University Health System, Singapore.
Article Synopsis
- This study examined how different surface treatments affect the strength and failure types of high-viscosity glass ionomer cements (HVGICs) attached to silver diamine fluoride (SDF)-treated carious dentin.
- Human premolars were used to simulate carious dentin, treated with SDF, and then various treatments were applied to analyze bond strength and failure modes.
- Results showed that polyacrylic acid led to the highest bond strength for self-cured cements, while a combination of phosphoric acid and resin-modified adhesive was best for light-cured cements, with different failure patterns observed for each type.
Dietary Chlorella vulgaris supplementation modulates health, microbiota and the response to oxidative stress of Atlantic salmon.
Sci Rep
October 2024
Department for Marine Aquaculture, Institute of Animal Breeding and Husbandry, Kiel University, Kiel, Germany.
Article Synopsis
- Microalgae, particularly Chlorella vulgaris, are being studied as health-boosting feed additives in aquaculture, specifically for Atlantic salmon, due to their ability to enhance immune function and manage stress responses.
- In the study, salmon were fed diets with varying levels of C. vulgaris and showed improved feed conversion and protein retention, with notable changes in gut microbial diversity and composition after feeding on higher amounts of the algae.
- Exposure to a stressor (peracetic acid) revealed that fish on higher algae diets exhibited less transcriptional stress response and increased antioxidant protein levels, suggesting that C. vulgaris may help mitigate stress effects in aquatic species.
Multilayer Gelatin-Supported BMP-9 Coating Promotes Osteointegration and Neo-Bone Formation at the n-CDHA/PAA Composite Biomaterial-Bone Interface.
Front Biosci (Landmark Ed)
September 2024
Department of Orthopedics, Chongqing Traditional Chinese Medicine Hospital, 400021 Chongqing, China.
Background: The development of biomaterials capable of accelerating bone wound repair is a critical focus in bone tissue engineering. This study aims to evaluate the osteointegration and bone regeneration potential of a novel multilayer gelatin-supported Bone Morphogenetic Protein 9 (BMP-9) coated nano-calcium-deficient hydroxyapatite/poly-amino acid (n-CDHA/PAA) composite biomaterials, focusing on the material-bone interface, and putting forward a new direction for the research on the interface between the coating material and bone.
Methods: The BMP-9 recombinant adenovirus (Adenovirus (Ad)-BMP-9/Bone Marrow Mesenchymal Stem Cells (BMSc)) was produced by transfecting BMSc and supported using gelatin (Ad-BMP-9/BMSc/Gelatin (GT).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!