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Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity.
Sci Adv
January 2020
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
To uncover the genetic basis of anthracycline-induced cardiotoxicity (AIC), we recently established a genetic suppressor screening strategy in zebrafish. Here, we report the molecular and cellular nature of , a salutary modifier mutant that affects . We showed that endothelial, but not myocardial or epicardial, activation confers AIC protection.
View Article and Find Full Text PDFSimvastatin modulates gene expression of key receptors in zebrafish embryos.
J Toxicol Environ Health A
September 2017
a CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n , Matosinhos , Portugal.
Nuclear receptors (NR) are involved in the regulation of several metabolic processes and it is well known that these constituents may be modulated by different chemicals classes, including pharmaceuticals that may activate or antagonize NR. In mammals, some pharmaceuticals modulate the transcription of pregnane X receptor, Pxr, peroxisome proliferator activated receptor, Ppars, and aryl hydrocarbon receptor, Ahr, affecting mRNA expression of genes belonging to various regulatory pathways, including lipid metabolism and detoxification mechanisms. The aim of this study was to determine the effects of simvastatin (SIM), an anticholesterolemic drug, on selected NR and AhR mRNA transcription levels during zebrafish early development.
View Article and Find Full Text PDFDanio rerio embryos on Prozac - Effects on the detoxification mechanism and embryo development.
Aquat Toxicol
September 2016
CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, Coastal and Marine Environmental Toxicology Lab, University of Porto, Rua dos Bragas, 289, 4050-123 Porto, Portugal; School of Marine Studies, Faculty of Science, Techonology and Environment, The University of South Pacific, Laucala Bay Road, Suva, Fiji Islands.
In the past decade the presence of psychopharmaceuticals, including fluoxetine (FLU), in the aquatic environment has been associated with the increasing trend in human consumption of these substances. Aquatic organisms are usually exposed to chronic low doses and, therefore, risk assessments should evaluate the effects of these compounds in non-target organisms. Teleost fish possess an array of active defence mechanisms to cope with the deleterious effects of xenobiotics.
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