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MOGAD: A comprehensive review of clinicoradiological features, therapy and outcomes in 4699 patients globally.
Autoimmun Rev
January 2025
Translational Neuroimmunology Group, Faculty of Medicine and Health, University of Sydney, Kids Neuroscience Centre, Children's Hospital at Westmead, Sydney, Australia; Sydney Medical School and Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Department of Neurology, Concord Hospital, Sydney, Australia. Electronic address:
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is one of the most common antibody-mediated CNS disorders. Optimal diagnostic and prognostic biomarkers remain unclear. Our aim was to clarify these biomarkers and therapeutic outcomes internationally.
View Article and Find Full Text PDFA cross-sectional study of fundus lesion characteristics in patients with acute visual impairment caused by COVID-19 infection.
Sci Rep
November 2024
Henan Provincial People's Hospital, Henan Eye Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
To investigate the characteristics of acute visual dysfunction and fundus lesions in patients with COVID-19 pneumonia. A retrospective case series study was conducted. Data from 48 patients (96 eyes) with COVID-19 infection who presented to our ophthalmology department with acute onset visual disturbance between December 5, 2022, and February 28, 2023 were collected.
View Article and Find Full Text PDFFindings of optical coherence tomography angiography of nasal optic disc hypoplasia.
Am J Ophthalmol Case Rep
December 2024
Department of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Fukuoka, Japan.
Purpose: This study aimed to present a case of a woman diagnosed with congenital nasal optic disc hypoplasia (NOH) in the right eye.
Observations: A woman in her 20s presented with a small optic disc, irregular optic disc margins with a double-ring sign, and wedge-shaped defects temporally extending from Mariotte's blind spot in the right eye. The radial peripapillary capillary (RPC) density around the optic nerve disc was examined using optical coherence tomography angiography (OCTA).
Spontaneous Focal Hemorrhage of Optic Disc in Peripapillary Hyperreflective Ovoid Mass-Like Structures.
Int Med Case Rep J
October 2024
Department of Ophthalmology, Shanghai Bright Eye Hospital, Shanghai, 200336, People's Republic of China.
Introduction: Spontaneous focal hemorrhage of optic disc in peripapillary hyperreflective ovoid mass-like structures (PHOMS) is rare. This study reports the image features of two cases of spontaneous hemorrhage of an optic disc in PHOMS.
Methods: : A 51-year-old woman complained of visual fatigue for 1 week.
3D growth and remodeling theory supports the hypothesis of staphyloma formation from local scleral weakening under normal intraocular pressure.
Biomech Model Mechanobiol
December 2024
Singapore Eye Research Institute (SERI), Singapore National Eye Centre (SNEC), Singapore, Singapore.
The purpose of this study was to assess whether growth and remodeling (G&R) theory could explain staphyloma formation from a local scleral weakening-as could occur from age-related elastin degradation, myopia progression, or other factors. A finite element model of a healthy eye was reconstructed, including the lamina cribrosa, the peripapillary sclera, and the peripheral sclera. The homogenized constrained mixture model was employed to simulate the adaptation of the sclera to alterations in its biomechanical environment over a duration of 13.
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