Learning with Noisy Labels (LNL) methods have been widely studied in recent years, which aims to improve the performance of Deep Neural Networks (DNNs) when the training dataset contains incorrectly annotated labels. Popular existing LNL methods rely on semantic features extracted by the DNN to detect and mitigate label noise. However, these extracted features are often spurious and contain unstable correlations with the label across different environments (domains), which can occasionally lead to incorrect prediction and compromise the efficacy of LNL methods. To mitigate this insufficiency, we propose Invariant Feature based Label Correction (IFLC), which reduces spurious features and accurately utilizes the learned invariant features that contain stable correlation to correct label noise. To the best of our knowledge, this is the first attempt to mitigate the issue of spurious features for LNL methods. IFLC consists of two critical processes: The Label Disturbing (LD) process and the Representation Decorrelation (RD) process. The LD process aims to encourage DNN to attain stable performance across different environments, thus reducing the captured spurious features. The RD process strengthens independence between each dimension of the representation vector, thus enabling accurate utilization of the learned invariant features for label correction. We then utilize robust linear regression for the feature representation to conduct label correction. We evaluated the effectiveness of our proposed method and compared it with state-of-the-art (sota) LNL methods on four benchmark datasets, CIFAR-10, CIFAR-100, Animal-10N, and Clothing1M. The experimental results show that our proposed method achieved comparable or even better performance than the existing sota methods. The source codes are available at https://github.com/yangbo1973/IFLC.
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http://dx.doi.org/10.1016/j.neunet.2024.106137 | DOI Listing |
Nat Commun
December 2024
Oncology Bioinformatics, Genentech, South San Francisco, CA, USA.
Based on the success of cancer immunotherapy, personalized cancer vaccines have emerged as a leading oncology treatment. Antigen presentation on MHC class I (MHC-I) is crucial for the adaptive immune response to cancer cells, necessitating highly predictive computational methods to model this phenomenon. Here, we introduce HLApollo, a transformer-based model for peptide-MHC-I (pMHC-I) presentation prediction, leveraging the language of peptides, MHC, and source proteins.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Faculty of Chemistry and Mineralogy, Universität Leipzig, Johannisallee 29, Leipzig 04103, Germany.
Two octa-coordinated lanthanum (III) complexes of deprotonated azaphosphor β-diketon and diimine ligands, [LnLQ] (L = [ClCHC(O)NP(O)(NCH)], Q = Phen (C1) and Bipy (C2)), were synthesized and characterized by elemental analysis, IR, and NMR spectra. X-ray crystallography revealed a distorted tetragonal antiprism LaO6N2 coordination geometry around the lanthanum atom in both compounds. Nano-sized complexes (Ć1 and Ć2) were synthesized via a sonochemical process and analyzed using SEM and XRPD.
View Article and Find Full Text PDFRadiother Oncol
January 2025
Radiophysics and MRI Physics Laboratory, Université Libre De Bruxelles (ULB), Brussels, Belgium; Department of Medical Physics, Institut Jules Bordet, Hôpital Universitaire de Bruxelles (H.U.B), Université Libre de Bruxelles (ULB), Brussels, Belgium. Electronic address:
Postoperative radiotherapy (RT) has been shown to effectively reduce disease recurrence and mortality in breast cancer (BC) treatment. A critical step in the planning workflow is the accurate delineation of clinical target volumes (CTV) and organs-at-risk (OAR). This literature review evaluates recent advancements in deep-learning (DL) and atlas-based auto-contouring techniques for CTVs and OARs in BC planning-CT images for RT.
View Article and Find Full Text PDFAppl Radiat Isot
January 2025
Legnaro National Laboratories, National Institute for Nuclear Physics, INFN-LNL, Viale dell'Università 2, 35020 Legnaro, Italy. Electronic address:
Targeted Radionuclide Therapy (TRT) is a medical technique exploiting radionuclides to combat cancer growth and spread. TRT requires a supply of radionuclides that are currently produced by either cyclotrons or nuclear research reactors. In this context, the ISOLPHARM project investigates the production of innovative radionuclides for medical applications.
View Article and Find Full Text PDFAsian Pac J Cancer Prev
September 2024
Department of Oncologic Pathology, South Egypt Cancer Institute, Assiut University, Egypt.
Objective: Neoadjuvant chemotherapy (NACT) is widely used for treating locally advanced Breast cancer (LABC). However, development of multidrug resistance (MDR) is the main underlying factor for chemoresistance. Technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) is a substrate for MDR.
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