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Protoilludane-Type and Related Nor-Sesquiterpenes from and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes. | LitMetric
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Protoilludane-Type and Related Nor-Sesquiterpenes from and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes.

Quan Fu Jing Yuan Tie-Hua Yang Jin-Hao Su Jing-Jing Zhang Xue-Wen Wu Hong-Ye Zhang Wei-Lie Xiao Chang-Bo Zheng Xiao-Li Li

J Nat Prod

Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, and School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650500, People's Republic of China.

Published: February 2024

Three nor-sesquiterpenes, phellinharts A-C (-), isolated from , exhibited unprecedented protoilludane and cerapicane-type structures. The structures of compounds - were elucidated via spectroscopic analysis, quantum chemical calculations, and X-ray diffraction. Potential biogenic pathways involving demethylation, ring cleavage, and rearrangement were proposed. Compounds - displayed potent anti-hypertrophic activities with low cytotoxicity (CC > 50 μM) in rat cardiomyocytes, underscoring their therapeutic potential.

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http://dx.doi.org/10.1021/acs.jnatprod.3c00985DOI Listing

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