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Keeping goblet cells unstressed: new insights into a general principle. | LitMetric

Keeping goblet cells unstressed: new insights into a general principle.

EMBO J

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.

Published: March 2024

The regulation of unfolded protein response (UPR) sensors has been studied for over 20 years, but IRE1β has remained a mystery. IRE1β is highly expressed in goblet cells: specialized epithelial cells that secrete mucus. Two articles in this issue show that IRE1β is held in an inactive state by the goblet cell-specific chaperone AGR2; upon dissociation of AGR2, IRE1β dimerizes and becomes active. This mechanism is reminiscent of the dynamic control by BiP of three other UPR sensors: IRE1α, PERK and ATF6.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10907747PMC
http://dx.doi.org/10.1038/s44318-024-00041-4DOI Listing

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