3D printing human tissue models derived from stem cells provides an increasingly popular tissue engineering strategy for probing biological questions. Here Yan et al. demonstrate how this technology can be used to model mature human neural tissues with functional neural networks in healthy and disease states.
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| http://dx.doi.org/10.1016/j.stem.2023.12.014 | DOI Listing |
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Laboratory of Cerebral Cortex Research, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.
Rewards are essential for motivation, decision-making, memory, and mental health. We identified the subventricular tegmental nucleus (SVTg) as a brainstem reward center. In mice, reward and its prediction activate the SVTg, and SVTg stimulation leads to place preference, reduced anxiety, and accumbal dopamine release.
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Deparment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
Systems biology tackles the challenge of understanding the high complexity in the internal regulation of homeostasis in the human body through mathematical modelling. These models can aid in the discovery of disease mechanisms and potential drug targets. However, on one hand the development and validation of knowledge-based mechanistic models is time-consuming and does not scale well with increasing features in medical data.
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Carney Institute for Brain Science, Department of Cognitive & Psychological Sciences, Brown University, Providence, Rhode Island, United States of America.
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