AI Article Synopsis
- Scientists studied a type of immune response in breast cancer by looking at special cells called germinal centers in lymph nodes and comparing them to tumor-related immune indicators.
- They found that patients with high levels of immune cells (sTILs) and specific immune structures had more germinal centers in their lymph nodes.
- The study suggests that examining these germinal centers could help understand how the body fights breast cancer and might be useful for future research.
Article Abstract
Background: Stromal tumour infiltrating lymphocytes (sTILs) and presence of tertiary lymphoid structures have been proposed as indicators of tumour-related immune response in breast cancer. An increased number of germinal centres (GCs) in lymph nodes is considered a sign of humoral immune reactivity.
Aims: It is unclear whether a relationship exists between number and size of GCs within tumour positive sentinel lymph nodes (SLNpos), sTILs and tertiary lymphoid structures within matched primary breast cancer and breast cancer subtype.
Methods: Axillary SLNpos from 175 patients with breast cancer were manually contoured in digitized haematoxylin and eosin stained sections. Total SLN area, GC number and GC area were measured in SLNpos with the largest metastatic area. To correct for SLN size, GC number and GC area were divided by SLN area. sTILs and presence of tertiary lymphoid structures were assessed in the primary breast cancer.
Results: A higher GC number and larger GC area were found in patients with high sTILs (≥2%) (both P < 0.001) and in patients with presence of tertiary lymphoid structures (P = 0.034 and P = 0.016). Triple negative and HER2-positive (N = 45) breast cancer subtypes had a higher GC number and higher sTILs compared to hormone receptor positive, HER2-negative breast cancer (N = 130) (P < 0.001 and P= 0.001).
Conclusion: This study suggests GCs measured within SLNpos might be useful indicators of the humoral anti-tumour immune response in breast cancer. Future studies are needed investigating underlying biological mechanisms and prognostic value of GCs in SLNs.
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| http://dx.doi.org/10.1016/j.prp.2024.155171 | DOI Listing |
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