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Noncoding variants and sulcal patterns in congenital heart disease: Machine learning to predict functional impact.
iScience
February 2025
Division of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Neurodevelopmental impairments associated with congenital heart disease (CHD) may arise from perturbations in brain developmental pathways, including the formation of sulcal patterns. While genetic factors contribute to sulcal features, the association of noncoding variants (ncDNVs) with sulcal patterns in people with CHD remains poorly understood. Leveraging deep learning models, we examined the predicted impact of ncDNVs on gene regulatory signals.
View Article and Find Full Text PDFRacism and Postpartum Blood Pressure in a Multiethnic Prospective Cohort.
Hypertension
February 2025
Department of Obstetrics and Gynecology (M.B., O.O., M.M., E.A.H., L.D.L.), University of Pennsylvania Perelman School of Medicine, Philadelphia.
Background: Postpartum hypertension is a key factor in racial-ethnic inequities in maternal mortality. Emerging evidence suggests that experiences of racism, both structural and interpersonal, may contribute to disparities. We examined associations between gendered racial microaggressions (GRMs) during obstetric care with postpartum blood pressure (BP).
View Article and Find Full Text PDFGut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals.
Nat Microbiol
January 2025
Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Article Synopsis
- Interest in how plant-based diets affect the gut microbiome is increasing, but there's limited research on how different diet patterns (omnivore, vegetarian, vegan) impact microbiome profiles across various populations.
- A study involving over 21,000 individuals found that gut microbiome profiles can effectively differentiate between these diet patterns, with a mean accuracy of 85%.
- Key findings show that omnivore microbiomes are heavily influenced by red meat consumption, which is linked to negative health markers, while vegan microbiomes are associated with healthier outcomes and overlap with specific food and soil microbes.
Effects of a Digital Intervention to Improve DASH and Blood Pressure Among US Adults.
Hypertension
February 2025
Duke Digital Health Science Center, Duke University, Durham, NC (S.A., M.B.B., E.T., G.G.B.).
Background: Dietary Approaches to Stop Hypertension (DASH) is a recommended first-line treatment for adults with hypertension, yet adherence to DASH is low. To evaluate the efficacy of a digital health intervention (DHI), compared with attention control, on changes in DASH adherence and blood pressure among adults with hypertension.
Methods: Nourish was a 12-month, parallel, 2-arm, randomized controlled trial of a virtually delivered DHI.
Oleoylethanolamide mitigates cardiometabolic disruption secondary to obesity induced by high-fat diet in mice.
Life Sci
December 2024
Cellular and Molecular Cardiology Research Unit, Institute of Biomedical Research of Santiago de Compostela (IDIS), Hospital Clínico Universitario de Santiago de Compostela, Área Sanitaria de Santiago de Compostela y Barbanza (SERGAS), Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:
Chronic lipid overnutrition has been demonstrated to promote cardiac dysfunction resulting from metabolic derangement, inflammation, and fibrosis. Oleoylethanolamide (OEA), an endogenous peroxisome proliferator activating receptor (PPAR)-α agonist, has been extensively studied for its metabolic properties. The aim of this study was to determine if OEA has beneficial effects on high-fat diet (HFD)-induced cardiac disruption in obese mice, focusing on the underlying pathological mechanisms.
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