AI Article Synopsis
- * Polyphenolic compounds show promise in combating these biofilms through various mechanisms, including disruption of bacterial membranes and blocking viral fusion, but they face issues like instability and low solubility.
- * Nanoformulations may enhance the antibacterial effectiveness of polyphenolics, offering a potential strategy to improve their therapeutic use against MDR bacteria and modify resistance.
Article Abstract
The emergence of multidrug-resistant (MDR) pathogens is a major problem in the therapeutic management of infectious diseases. Among the bacterial resistance mechanisms is the development of an enveloped protein and polysaccharide-hydrated matrix called a biofilm. Polyphenolics have demonstrated beneficial antibacterial effects. Phenolic compounds mediate their antibiofilm effects via disruption of the bacterial membrane, deprivation of substrate, protein binding, binding to adhesion complex, viral fusion blockage and interactions with eukaryotic DNA. However, these compounds have limitations of chemical instability, low bioavailability, poor water solubility and short half-lives. Nanoformulations offer a promising solution to overcome these challenges by enhancing their antibacterial potential. This review summarizes the antibiofilm role of polyphenolics, their underlying mechanisms and their potential role as resistance-modifying agents.
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| http://dx.doi.org/10.2217/fmb-2023-0175 | DOI Listing |
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