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Expert consensus on antimicrobial resistance research priorities to focus development and implementation of antibacterial vaccines and monoclonal antibodies.
Euro Surveill
November 2024
Infection Control Program, Geneva University Hospitals and Faculty of Medicine, WHO Collaborating Center, Geneva, Switzerland.
To reduce antimicrobial resistance (AMR), pathogen-specific AMR burden data are crucial to guide target selection for research and development of vaccines and monoclonal antibodies (mAbs). We identified knowledge gaps through previously conducted systematic reviews, which informed a Delphi expert consultation on future AMR research priorities and harmonisation strategies to support data-driven decision-making. Consensus (≥80% agreement) on importance and feasibility of research topics was achieved in two rounds, involving 24 of 39 and 19 of 24 invited experts, respectively.
View Article and Find Full Text PDFEnvironmental contamination by veterinary medicinal products and their implications in the conservation of the endangered Pyrenean Capercaillie (Tetrao urogallus aquitanicus).
Ecotoxicol Environ Saf
December 2024
Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC, Valdeolmos 28130, Spain. Electronic address:
The endangered Pyrenean Capercaillie (Tetrao urogallus aquitanicus) inhabits perennial forests of the Pyrenees (Spain, France and Andorre). Feces of domestic animals (e.g.
View Article and Find Full Text PDFA call to action: the SHEA research agenda to combat healthcare-associated infections.
Infect Control Hosp Epidemiol
October 2024
University of Michigan, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Infections in decompensated cirrhosis: Pathophysiology, management, and research agenda.
Hepatol Commun
October 2024
Department of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
Bacterial infections in patients with cirrhosis lead to a 4-fold increase in mortality. Immune dysfunction in cirrhosis further increases the risk of bacterial infections, in addition to alterations in the gut microbiome, which increase the risk of pathogenic bacteria. High rates of empiric antibiotic use contribute to increased incidence of multidrug-resistant organisms and further increases in mortality.
View Article and Find Full Text PDFCarlos Asensio and the dawn of molecular microbial ecology.
Int Microbiol
October 2024
Directorate-General Research and Innovation (Ret.), European Commission 1049, Brussels, Belgium.
At near 50 years of the discovery of microcins, this article highlights the pivotal-but under-recognised-influence of Spanish biochemist Carlos Asensio (1925-1982) in contemporary microbiology, featuring the epistemological, sociological, and cultural impact of his scientific achievements. At a time when the intestinal microbiome is central to current biomedical research, it is due to emphasise his role in the establishment of new scientific fields that are now considered fundamental. Despite his premature death at the peak of his conceptual and experimental creativity, many of his ideas about microbial communication in complex communities inspired a generation of researchers and opened new topics reach to this day.
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