AI Article Synopsis
- Therapeutic drug monitoring (TDM) is a crucial tool for ensuring drug safety and effectiveness by tracking the concentration of medications in blood or plasma.
- TDM, when paired with real-time dosage adjustments, plays an essential role in managing glycopeptide antimicrobial therapies, which require a good grasp of pharmacokinetics and pharmacodynamics.
- Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) is the preferred method for accurately measuring antibiotic levels, providing a detailed analysis for several glycopeptide antibiotics including vancomycin and teicoplanin.
Article Abstract
Therapeutic drug monitoring (TDM) is a critical clinical tool used to optimize the safety and effectiveness of drugs by measuring their concentration in biological fluids. These fluids are primarily plasma or blood. TDM, together with real-time dosage adjustment, contributes highly to the successful management of glycopeptide antimicrobial therapies. Understanding pharmacokinetic/pharmacodynamic (PK/PD) properties is vital for optimizing antimicrobial therapies, as the efficacy of these therapies depends on both the exposure of the patient to the drug (PK) and pharmacodynamic (PD) parameters such as the in vitro estimated minimum drug concentration that inhibits bacterial growth (MIC). Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) is widely recognized as the gold standard for measuring small molecules, such as antibiotics. This review provides a comprehensive overview of LC-MS/MS methods available for TDM of glycopeptide antibiotics, including vancomycin, teicoplanin, dalbavancin, oritavancin, and telavancin.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10831154 | PMC |
| http://dx.doi.org/10.1016/j.jmsacl.2023.12.003 | DOI Listing |
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