AI Article Synopsis
- - This study aimed to see how different exercise intensities affect mental health symptoms in older adults and whether specific genetic factors, like brain-derived neurotrophic factor (BDNF) and apolipoprotein E (ApoE), influence these effects.
- - The research analyzed data from a trial that compared high-intensity aerobic training, moderate-intensity aerobic training, and a control group over six months, focusing on symptoms of depression, anxiety, and stress.
- - Results revealed that while the overall exercise intervention didn't change mental health symptoms, those with the ε4 genetic variation experienced a significant reduction in perceived stress when engaging in high-intensity exercise, unlike non-carriers.
Article Abstract
Background/objective: (1) Examine the role of exercise intensity on mental health symptoms in a community-based sample of older adults. (2) Explore the moderating role of genetic variation in brain-derived neurotrophic factor () and apolipoprotein E () on the effects of exercise on mental health symptoms.
Method: This study is a secondary analysis of a three-arm randomized controlled trial, comparing the effects of 6 months of high-intensity aerobic training vs. moderate-intensity aerobic training vs. a no-contact control group on mental health symptoms assessed using the Depression, Anxiety, and Stress Scale (DASS). The Val66Met polymorphism and ε4 carrier status were explored as genetic moderators of exercise effects on mental health symptoms.
Results: The exercise intervention did not influence mental health symptoms. The Val66Met polymorphism did not moderate intervention effects on mental health symptoms. ε4 carrier status moderated the effect of intervention group on perceived stress over 6 months, such that ε4 carriers, but not non-carriers, in the high-intensity aerobic training group showed a decline in perceived stress over 6 months.
Conclusions: ε4 carrier status may modify the benefits of high-intensity exercise on perceived stress such that ε4 carriers show a greater decline in stress as a result of exercise relative to non- ε4 carriers.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10831729 | PMC |
| http://dx.doi.org/10.1016/j.ijchp.2024.100443 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!