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| http://dx.doi.org/10.1016/j.jds.2023.04.016 | DOI Listing |
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In vivo endocultivation of CAD/CAM hybrid scaffolds in the omentum majus in miniature pigs.
J Craniomaxillofac Surg
November 2024
Department of Oral and Maxillofacial Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Purpose: Correction of bony mandibular defects is a challenge in oral and maxillofacial surgery due to aesthetic and functional requirements. This study investigated the potential of a novel hybrid scaffold for bone regeneration and degradation assessment of the ceramic within the omentum majus over 6 months and the extent to which rhBMP-2 as a growth factor, alone or combined with a hydrogel, affects regeneration.
Materials And Methods: In this animal study, 10 Göttingen minipigs each had one scaffold implanted in the greater omentum.
Assessment of rhBMP-2-loaded bovine hydroxyapatite granules in the guided bone regeneration of critical bone defect in rat mandible bone.
J Dent Sci
January 2024
Department of Surgery, University of Salamanca, Salamanca, Spain.
Correlation between two-dimensional micro-CT and histomorphometry for assessment of the implant osseointegration in rabbit tibia model.
Biomater Res
April 2021
Department of Orthopedic Surgery, SMG-SNU Boramae Medical Center, Boramae-ro 5-gil 20, Dongjak-gu, Seoul, 07061, South Korea.
Background: Histology is considered as a gold standard for analyzing bone architecture. However, histomorphometry is a destructive method and only offers the bone information of a limited location. Micro-computed tomography (μCT) is a non-destructive technology and provides a slice at any site.
View Article and Find Full Text PDFDevelopment and Assessment of a 3D-Printed Scaffold with rhBMP-2 for an Implant Surgical Guide Stent and Bone Graft Material: A Pilot Animal Study.
Materials (Basel)
December 2017
Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea.
In this study, a new concept of a 3D-printed scaffold was introduced for the accurate placement of an implant and the application of a recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded bone graft. This preliminary study was conducted using two adult beagles to evaluate the 3D-printed polycaprolactone (PCL)/-tricalcium phosphate (-TCP)/bone decellularized extracellular matrix (bdECM) scaffold conjugated with rhBMP-2 for the simultaneous use as an implant surgical guide stent and bone graft material that promotes new bone growth. Teeth were extracted from the mandible of the beagle model and scanned by computed tomography (CT) to fabricate a customized scaffold that would fit the bone defect.
View Article and Find Full Text PDFEffect of drug-loaded TiO nanotube arrays on osseointegration in an orthodontic miniscrew: an in-vivo pilot study.
Biomed Microdevices
October 2017
Research Institute for Dental Engineering, Gangneung-Wonju National University, Gangneung, 25457, South Korea.
Osseointegration was evaluated for the surface of miniscrews with TiO nanotube arrays containing drugs in this in-vivo study. The diameter and length of the TiO nanotube arrays were about 70 nm and 5 μm, respectively. Recombinant human bone morphogenetic protein-2 (rhBMP-2) or ibuprofen was loaded in the TiO nanotube arrays with 12 miniscrews.
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