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Two new compounds from biotransformation of glycyrrhetinic acid. | LitMetric
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Two new compounds from biotransformation of glycyrrhetinic acid.

Zehao Xie Xinxin Gu Aman Dekebo Shaozhong Wei Xuebo Hu

Nat Prod Res

Institute for Medicinal Plants, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China, Innovation Academy of International Traditional Chinese Medicinal Materials, Huazhong Agricultural University, Wuhan, China, National-Regional Joint Engineering Research Center in Hubei for Medicinal Plant Breeding and Cultivation, Huazhong Agricultural University, Wuhan, China, Medicinal Plant Engineering Research Center of Hubei Province, Huazhong Agricultural University, Wuhan, China.

Published: February 2024

Glycyrrhetinic acid may undergo biotransformation to obtain derivatives with stronger pharmacological activity and fewer side effects. This study used 19 fungi to biotransform glycyrrhetinic acid and yielded two compounds namely bicyclo(14.15.27)glycyrrhetinic acid () and 2-ene-glycyrrhetinic acid () from the glycyrrhetinic acid metabolites of two fungi, B05.10 ATCC 11542 and ATCC 12066. Compound inhibited HMEC-1 cell proliferation in a concentration-dependent manner (IC=239.1 µ M), but showed no significant cytotoxicity to A549 cells.

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 Source
http://dx.doi.org/10.1080/14786419.2024.2306918DOI Listing

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