AI Article Synopsis
- * A study analyzed serum levels of 17 biomarkers in 92 patients with this injury and found significant differences compared to 51 controls, indicating elevated levels of markers linked to blood vessel damage, inflammation, and nerve protection.
- * The findings of this research enhance understanding of the disease's mechanisms, potentially aiding the development of more objective diagnostic methods.
Article Abstract
Hand-arm vibration injury is a well-known occupational disorder that affects many workers globally. The diagnosis is based mainly on quantitative psychophysical tests and medical history. Typical manifestations of hand-arm vibration injury entail episodes of finger blanching, Raynaud's phenomenon (RP) and sensorineural symptoms from affected nerve fibres and mechanoreceptors in the skin. Differences in serum levels of 17 different biomarkers between 92 patients with hand-arm vibration injury and 51 controls were analysed. Patients with hand-arm vibration injury entailing RP and sensorineural manifestations showed elevated levels of biomarkers associated with endothelial injury or dysfunction, inflammation, vaso- or neuroprotective compensatory, or apoptotic mechanisms: intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1); thrombomodulin (TM), heat shock protein 27 (HSP27); von Willebrand factor, calcitonin gene-related peptide (CGRP) and caspase-3. This study adds important knowledge on pathophysiological mechanisms that can contribute to the implementation of a more objective method for diagnosis of hand-arm vibration injury.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10834969 | PMC |
| http://dx.doi.org/10.1038/s41598-024-52782-1 | DOI Listing |
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Article Synopsis
- Occupational exposure to vibration from hand-held tools can lead to hand-arm vibration syndrome (HAVS), as shown in the case of a 39-year-old dental technician who experienced chronic wrist pain, numbness, and tingling for three years after five years of repetitive tool use.
- She was diagnosed with bilateral median nerve neuropathy, mild carpal tunnel syndrome, and had MRI results indicating soft tissue damage due to repetitive strain injury, particularly in her dominant right wrist.
- A workplace health risk assessment identified high-risk tasks associated with her symptoms, leading to modifications and monitoring protocols that helped stabilize her condition.
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