The observational study aims to evaluate inflammatory markers, cell adhesion molecules (CAM) and endothelial dysfunction markers as biomarkers in Indian ACS patients with no conventional risk factors. The study population included 110 healthy individuals and 102 ACS patients without any history of conventional risk factors, except smoking and alcoholism, were included. Patient history, biochemical parameters and levels of biomarkers were estimated. ACS patients had a significant elevation in the circulatory levels of biomarkers, such as IL-6, TNF-α, MCP1, MMP9, VCAM1, ICAM1 and E-selectin. CAM, inflammatory and endothelial biomarkers could help devise strategies for early, effective treatment of ACS.
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http://dx.doi.org/10.1016/j.ihj.2024.01.016 | DOI Listing |
Intern Emerg Med
January 2025
Faculty of Medicine, Department of Emergency Medicine, Akdeniz University, Antalya, Turkey.
Patients presenting with suspected acute coronary syndrome (ACS) in the emergency department (ED) require rapid and accurate electrocardiographic (ECG) evaluation. This study aims to assess conventional ECG markers for diagnosing non-ST-elevation ACS (NSTE-ACS) in patients with chest discomfort and right bundle branch block (RBBB). A nested case-control design was employed to compare patients with RBBB admitted to the ED for suspected cardiac ischemia, focusing on those who developed NSTE-ACS versus those who did not.
View Article and Find Full Text PDFJ Cardiothorac Surg
January 2025
Department of Intensive Care Medicine, Hangzhou TCM, Hospital Affiliated to Zhejiang Chinese Medicine University, No.1630, Huanding Road, Shangcheng District, Hangzhou, 310044, China.
Background & Objective: Timely intervention for Acute coronary syndrome (ACS) could effectively reduce the mortality rate of ACS patients. This study aimed to investigate the clinical significance of miR-30c-5p for ACS and to provide a convenient biomarker for diagnosing of ACS.
Methods: Baseline information was collected from a total of 173 subjects (98 ACS subjects and 65 healthy subjects).
HPB (Oxford)
December 2024
Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH, United States. Electronic address:
Objective: We sought to develop a machine learning (ML) preoperative model to predict bile leak following hepatectomy for primary and secondary liver cancer.
Methods: An eXtreme Gradient Boosting (XGBoost) model was developed to predict post-hepatectomy bile leak using data from the ACS-NSQIP database. The model was externally validated using data from hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) multi-institutional databases.
ACS Appl Mater Interfaces
January 2025
School of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong 999077, China.
Clin Cancer Res
January 2025
Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Background: The long-term effect of adipose-derived mesenchymal stromal cells (ASCs) to restore radiation-induced salivary gland hypofunction in previous head and neck cancer patients have not been validated in larger settings.
Methods: The study was the 12-months follow-up of a randomised trial, including patients with hyposalivation. Patients were randomised to receive allogeneic ASCs or placebo in the submandibular glands.
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