Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S1470-2045(23)00677-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gastric cancer remains a major global health concern with high incidence and mortality rates, particularly in East Asia. Patients often have poor outcomes due to limited treatment efficacy. Zolbetuximab, a monoclonal antibody targeting claudin 18.
View Article and Find Full Text PDFFirst-line treatment with zolbetuximab plus CAPOX for ClDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: a cost-effectiveness analysis.
Therap Adv Gastroenterol
November 2024
Department of Pharmacy, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, Fujian Province 350001, China.
Article Synopsis
- * A cost-effectiveness analysis using a 10-year Markov model found that in the U.S., the combination treatment resulted in an incremental cost-effectiveness ratio (ICER) of $821,515.65 per quality-adjusted life-year (QALY) gained, while in China the ICER was $273,568.01/QALY gained.
- * The treatment was determined not to be cost-effective according to common willingness-to-pay thresholds, suggesting that the
Skin decontamination with and without water irrigation.
Disaster Med Public Health Prep
October 2024
Arizona Poison and Drug Information Center, College of Pharmacy, University of Arizona, Tucson, AZ, USA.
Objective: Rinsing only with water or washing with soap and water are common methods of skin decontamination for skin contaminated during a chemical hazard release. The null hypothesis was that a 15-minute water irrigation (decontamination method 1) would not be superior to decontamination using a microfiber towel, followed by a wet wipe (Signature Select Softly Flushable Tissue Better Living Brands LLC, Pleasanton, CA), followed by using another microfiber towel (decontamination method 2).
Methods: A simulated contaminant (Magic Fluorescent Glow Paint for Face and Body, iLC Shenzhen Fulimei Technology Co.
Health-related quality of life in patients with CLDN18.2-positive, locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma: results from the SPOTLIGHT and GLOW clinical trials.
ESMO Open
August 2024
Department of Oncology, Asan Medical Center, University of Ulsan, Seoul, Republic of Korea. Electronic address:
Background: First-line zolbetuximab plus chemotherapy (SPOTLIGHT, mFOLFOX6; GLOW, CAPOX) significantly improved progression-free survival (PFS) and overall survival (OS) versus placebo plus chemotherapy in patients with human epidermal growth factor receptor 2-negative, locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma whose tumors were claudin 18 isoform 2-positive in the phase III SPOTLIGHT (NCT03504397) and GLOW (NCT03653507) studies. We present patient-reported outcomes (PROs) from these studies.
Materials And Methods: Health-related quality of life (HRQoL) was measured in the full analysis sets using the European Organisation for Research and Treatment of Cancer Quality of Life of Cancer Patients Core Questionnaire (QLQ-C30) and Oesophago-Gastric Module (QLQ-OG25), Global Pain, and 5-level EQ-5D (EQ-5D-5L) questionnaires.
Glucosinolate Hydrolytic Products-A Multi-Arm Warrior.
J AOAC Int
October 2024
Department of Women and Baby, Sunnybrook Research Institute, 2075 Bayview Ave, North York, Ontario, M4N 3M5, Canada.
Background: Glucosinolates (GSLs) are the most controversial yet ignored class of phytochemicals. These are the middleman phytochemicals that have low bioactivity. But once there is any injury in the plant-manmade, insect caused, or natural-magic happens.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!