AI Article Synopsis
Article Abstract
In this study there were utilized a combination of Fourier transform infrared spectroscopy in attenuated total reflection mode (ATR-FTIR) and partial least squares (PLS) regression method to develop quantitative models for determining the concentration of ademetionine in commercial tablets. The established and validated models were specifically designed for a commercial product containing ademetionine 1,4-butandiesulfonate. The coefficient of determination for the developed model was 0.999. Relative standard deviation (RSD) does not exceed 1.6% for repeatability and intermediate accuracy, which meets the international ICH and AOAC requirements for the method performance. The validation results effectively confirmed that this method is suitable and meets the current requirements for analytical methods in drug quality control. Consequently, this approach can be used for routine ademetionine analysis in pharmaceutical products and has the potential to be applied to other active pharmaceutical ingredients (APIs) in drug quality control.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpba.2024.115991 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Large-Current CO Electromethanation Through Active Hydrogen Regulation Over Carbon Nitride.
Small
January 2025
Key Laboratory for Green Chemical Technology of Ministry of Education, Collaborative Innovation Centre of Chemical Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.
Electromethanation of CO has received intensive attention due to its high calorific value and convenient storage along with transportation to accommodate industrial demands. However, it is limited by sluggish multi-step proton-coupled electron transfer kinetics and undesired H coupling under high current density, posing great challenges to its commercialization. Herein, carbon nitride (CN) with superior hydrogen adsorption ability is used as an active-hydrogen adsorption and supply material.
View Article and Find Full Text PDFA new approach to assess post-mortem interval: A machine learning-assisted label-free ATR-FTIR analysis of human vitreous humor.
Spectrochim Acta A Mol Biomol Spectrosc
February 2025
Department of Life and Environmental Sciences, Polytechnic University of Marche, Via Brecce Bianche, 60131 Ancona, Italy.
A crucial issue in forensics is determining the post-mortem interval (PMI), the time between death and the finding of a body. Despite various methods already employed for its estimation, only approximate values are currently achievable. Vitreous humor (VH) is an avascular tissue between the lens and the retina, mainly composed by a collagen fibers network, hyaluronic acid, and hyalocytes.
View Article and Find Full Text PDFSimultaneous determination of glucose and albumin in human urine using attenuated total reflection Fourier-transform infrared spectroscopy.
Anal Methods
December 2024
Monash Biospectroscopy Group and School of Chemistry, Monash University, Clayton, Victoria, Australia.
The ability to quantify albuminuria and glucose is important in identifying conditions such as cardiovascular disease (CVD), chronic kidney disease (CKD), and diabetes. This study utilized Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy to analyze aqueous urine samples spiked with bovine serum albumin (BSA) and glucose at different concentrations. The aim was to determine the limit of detection of the technology using aqueous samples for the future development of a pathological prediction model.
View Article and Find Full Text PDFA Multimodal Spectroscopic Approach Combining Mid-infrared and Near-infrared for Discriminating Gram-positive and Gram-negative Bacteria.
Anal Chem
November 2024
Monash Biospectroscopy Group, School of Chemistry, Faculty of Science, Monash University, Clayton, Victoria 3168, Australia.
The rapid and accurate identification of pathogenic bacteria is crucial for combating the growing threat of antibiotic resistance, nosocomial infections, and food safety concerns. This study presents a novel and comprehensive comparison of two vibrational spectroscopic techniques - attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and a low-cost miniature near-infrared (NIR) spectrometer - for distinguishing Gram-positive and Gram-negative bacterial samples grown using the same stock media solution. This is the first report of NIR spectroscopy being applied to differentiate Gram-positive and Gram-negative bacteria, as well as the first direct comparison of ATR-FTIR and NIR for the combined multimodal analysis of clinical bacterial isolates.
View Article and Find Full Text PDFImplications of crystal disorder on the solid-state stability of olanzapine.
J Pharm Sci
January 2025
Research Center Pharmaceutical Engineering GmbH (RCPE), 8010 Graz, Austria; Graz University of Technology, Institute of Process and Particle Engineering, 8010 Graz, Austria. Electronic address:
Mechanical perturbations of drug during solid pharmaceutical processing like milling can often generate crystal disorder posing serious implications to drug's stability. While physical changes like amorphization, recrystallization, polymorphism of the disordered drugs are extensively studied and reported in the literature, the propensities and inter-dependencies of recrystallization and degradation of disordered drugs have seldom received deep attention. Previous investigations from our lab have explored some of these interplays, aiming to develop predictive stability models.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!