AI Article Synopsis
- Depression is common among epilepsy patients, and their brain activity can reveal links between epilepsy and depression symptoms.
- A study analyzed brain recordings from 34 epilepsy patients to correlate brain activity patterns (spectral power and phase amplitude coupling) with depressive symptoms assessed using the Beck Depression Inventory-II.
- An elevated phase amplitude coupling signal was found in patients with high depression scores, particularly in brain regions associated with depression, indicating that this could serve as a biomarker for comorbid depression and a target for neuromodulation treatments.
Article Abstract
Depression is prevalent in epilepsy patients and their intracranial brain activity recordings can be used to determine the types of brain activity that are associated with comorbid depression. We performed case-control comparison of spectral power and phase amplitude coupling (PAC) in 34 invasively monitored drug resistant epilepsy patients' brain recordings. The values of spectral power and PAC for one-minute segments out of every hour in a patient's study were correlated with pre-operative assessment of depressive symptoms by Beck Depression Inventory-II (BDI). We identified an elevated PAC signal (theta-alpha-beta phase (5-25 Hz)/gamma frequency (80-100 Hz) band) that is present in high BDI scores but not low BDI scores adult epilepsy patients in brain regions implicated in primary depression, including anterior cingulate cortex, amygdala and orbitofrontal cortex. Our results showed the application of PAC as a network-specific, electrophysiologic biomarker candidate for comorbid depression and its potential as treatment target for neuromodulation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923038 | PMC |
| http://dx.doi.org/10.1016/j.yebeh.2024.109659 | DOI Listing |
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