We demonstrate hydrohalogenation of aliphatic alkenes with collidine·HX salts through dual photoredox/cobalt catalysis. The dual catalysis enables conversion of a proton and a halide anion from collidine·HX salt to a nucleophilic hydrogen radical equivalent and an electrophilic halogen radical equivalent and delivery of them to an alkene moiety. This protocol allows for introduction of fluorine, chlorine, bromine, or iodine atom to alkene, producing highly functionalized alkyl halides.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jacs.3c10133 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intertransverse process block versus subcostal transversus abdominis plane block in patients undergoing laparoscopic radical gastrectomy: a prospective randomized controlled trial.
BMC Anesthesiol
January 2025
The Yancheng Clinical College of Xuzhou Medical University, No 166 Yulong Road, Yancheng, Jiangsu, 224000, China.
Background: Laparoscopic radical gastrectomy has been reported to be associated with substantial trauma and pain. This study compared the impact of ultrasound-(US)-guided, bilateral, double-injection intertransverse process block (ITPB) on postoperative analgesia with subcostal transversus abdominis plane block (TAPB) in patients who were undergoing laparoscopic radical gastrectomy.
Methods: Sixty-two patients who were undergoing laparoscopic radical gastrectomy surgery under general anesthesia were included.
Impact of Intraoperative Opioid Use and a Combined Anesthesia Regimen in Patients Undergoing Radical Prostatectomy for Prostate Cancer in a Single-Center Cohort.
J Clin Med
December 2024
Department of Urology, University Hospital of the LMU Munich, 81377 Munich, Germany.
Higher intraoperative opioid doses may be associated with worse long-term oncological outcomes after radical prostatectomy (RP) for prostate cancer. We aimed to evaluate the impact of higher doses of intraoperative opioids and type of anesthesia on biochemical recurrence (BCR) and mortality after RP in a high-volume tertiary center. All patients underwent RP at our center between 2015 and 2021.
View Article and Find Full Text PDFCorrelation of physicochemical properties with antioxidant activity in phenol and thiophenol analogues.
Sci Rep
January 2025
Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA, 02125, USA.
Oxidative stress, associated with excessive production of reactive oxygen and nitrogen species (ROS, RNS), contributes to the development and progression of many ailments, such as aging, cardiovascular diseases, Alzheimer's disease, Parkinson's disease, diabetes, cancer, preeclampsia or multiple sclerosis. While phenols and polyphenols are the most studied antioxidants structurally similar compounds such as anilines or thiophenols are sporadically analyzed despite their radical scavenging potential. This work assesses the impact of structural features of phenols and thiophenols on their antioxidant activity.
View Article and Find Full Text PDFOutcomes of Laparoscopic Radical Hysterectomy in Ia1-Ib1 Cervical Cancer Patients: A Multi-Center Study with 10 Years' Experiences in the Real World.
Ann Surg Oncol
December 2024
Department of Gynecologic Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine Central, South University/Hunan Cancer Hospital, Changsha, People's Republic of China.
Article Synopsis
- The study assessed laparoscopic radical hysterectomy (LRH) outcomes in early-stage, low-risk cervical cancer patients compared to open abdominal radical hysterectomy (OARH).
- In low-risk cases, 5-year overall and progression-free survival rates were similar for LRH (98.6% OS, 97.6% PFS) and OARH (99.3% OS, 98.4% PFS), with no significant differences found.
- Conversely, in high-risk patients, LRH showed lower survival rates compared to OARH, indicating the need for careful surgical approach selection based on risk factors and imaging prior to surgery.
Resorcimoline as a Novel Therapeutic Agent Attenuates Ischemia-Reperfusion Injury in Hind Extremities.
Ann Vasc Surg
December 2024
Department of Cardiovascular Surgery, Oita University Faculty of Medicine, Oita, Japan.
Background: Acute ischemia in the hind extremities is a dangerous disease that causes irreversible damage. Revascularization procedures are important to prevent muscle damage, but these treatments may induce additional damage, also known as ischemia-reperfusion injury. The role of free radicals as pivotal mediators of ischemia-reperfusion injury remains a prominent hypothesis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!