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Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study.
JAMA Netw Open
January 2025
Alzheimer Center Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Importance: Baseline cerebral microbleeds (CMBs) and APOE ε4 allele copy number are important risk factors for amyloid-related imaging abnormalities in patients with Alzheimer disease (AD) receiving therapies to lower amyloid-β plaque levels.
Objective: To provide prevalence estimates of any, no more than 4, or fewer than 2 CMBs in association with amyloid status, APOE ε4 copy number, and age.
Design, Setting, And Participants: This cross-sectional study used data included in the Amyloid Biomarker Study data pooling initiative (January 1, 2012, to the present [data collection is ongoing]).
Revealing the Enigma: A Deep Dive Into Submandibular Adenoid Cystic Carcinoma and Its Management.
Cureus
November 2024
Radiation Oncology, Faculty of Medicine and Pharmacy - Mohammed First University, oujda, MAR.
Adenoid cystic carcinoma (ACC) of the submandibular gland is a rare and highly aggressive malignancy, distinguished by its tendency for perineural invasion and distant metastasis, particularly to the lungs and bones. The management of ACC is challenging due to its biological variability and the absence of specific randomized controlled trials to guide treatment. This report aims to encapsulate the clinical features, histological profile, diagnostic workup, and management options for submandibular gland ACC, with an emphasis on recent advancements in understanding and treatment.
View Article and Find Full Text PDFDissemination Presenting With Encephalopathy and Epidural Abscess.
Case Rep Infect Dis
November 2024
Department of Radiodiagnosis, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India.
Staphylococcal infection is a common bacterial disease with common clinical features. Untreated infection, especially in immunosenescence cases, can affect other organs. This can lead to multiorgan dysfunction and cause increased morbidity and mortality.
View Article and Find Full Text PDFA worldwide study of subcortical shape as a marker for clinical staging in Parkinson's disease.
NPJ Parkinsons Dis
November 2024
Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
Alterations in subcortical brain regions are linked to motor and non-motor symptoms in Parkinson's disease (PD). However, associations between clinical expression and regional morphological abnormalities of the basal ganglia, thalamus, amygdala and hippocampus are not well established. We analyzed 3D T1-weighted brain MRI and clinical data from 2525 individuals with PD and 1326 controls from 22 global sources in the ENIGMA-PD consortium.
View Article and Find Full Text PDFSingle-cell RNA sequencing: an emerging tool revealing dysregulated innate and adaptive immune response at single cell level in Kawasaki disease.
Expert Rev Clin Immunol
January 2025
Department of Pediatrics, Allergy Immunology Unit, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Article Synopsis
- Kawasaki disease (KD) is a serious condition primarily affecting children, characterized by fever and inflammation of medium blood vessels, but its exact causes are still unclear despite ongoing research.
- Recent advancements in single-cell RNA sequencing (scRNA-seq) have enhanced our ability to study the immune response and molecular pathways involved in KD, offering insights beyond what was previously possible.
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