AI Article Synopsis
- STATs are cytoplasmic transcription factors that transmit signals from cell surface receptors to the nucleus, with STAT3 being particularly involved in various human cancers.
- STAT3 activation has been linked to the development of multiple cancers, including breast, lung, and prostate cancers.
- Inhibiting STAT3 activation can trigger apoptosis in tumor cells, suggesting potential therapeutic approaches for cancer treatment.
Article Abstract
A category of cytoplasmic transcription factors called STATs mediates intracellular signaling, which is frequently generated at receptors on cell surfaces and subsequently sent to the nucleus. STAT3 is a member of a responsible for a variety of human tumor forms, including lymphomas, hematological malignancies, leukemias, multiple myeloma and several solid tumor types. Numerous investigations have demonstrated constitutive STAT3 activation lead to cancer development such as breast, head and neck, lung, colorectal, ovarian, gastric, hepatocellular, and prostate cancers. It's possible to get a hold of the book here. Tumor cells undergo apoptosis when STAT3 activation is suppressed. This review highlights the STAT3 activation and inhibition which can be used for further studies.
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| http://dx.doi.org/10.2174/0113895575254012231024062619 | DOI Listing |
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