AI Article Synopsis
- Rodent models play a crucial role in studying kidney development and diseases such as acute kidney injury (AKI) and its progression to chronic kidney disease (CKD).
- Recent advancements have allowed researchers to create models that reflect various causes of AKI and its related complications, aiding both basic research and drug development.
- However, these models have significant limitations in accurately representing human conditions, highlighting the need for improved models that better mimic the complexities of human kidney disease.
Article Abstract
Despite known drawbacks, rodent models are essential tools in the research of renal development, physiology, and pathogenesis. In the past decade, rodent models have been developed and used to mimic different etiologies of acute kidney injury (AKI), AKI to chronic kidney disease (CKD) transition or progression, and AKI with comorbidities. These models have been applied for both mechanistic research and preclinical drug development. However, current rodent models have their limitations, especially since they often do not fully recapitulate the pathophysiology of AKI in human patients, and thus need further refinement. Here, we discuss the present status of these rodent models, including the pathophysiologic compatibility, clinical translational significance, key factors affecting model consistency, and their main limitations. Future efforts should focus on establishing robust models that simulate the major clinical and molecular phenotypes of human AKI and its progression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208034 | PMC |
| http://dx.doi.org/10.1152/ajprenal.00402.2023 | DOI Listing |
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