AI Article Synopsis
- - The case report discusses a 13-year-old male with TBG-CD who had an asymptomatic follicular adenoma that unexpectedly shrank without treatment.
- - Despite low levels of thyroxin and TBG, the patient presented with a swollen thyroid gland and a nodule detected through ultrasonography.
- - Genetic testing confirmed a variant leading to TBG deficiency; the findings suggest that monitoring via ultrasound may be sufficient for similar cases rather than immediate treatment.
Article Abstract
Complete deficiency of thyroxin-binding globulin (TBG-CD) is not commonly associated with clinical symptoms, and little is known about thyroid tumors associated with TBG-CD. We present a case report of an asymptomatic follicular adenoma that spontaneously shrank in a patient with TBG-CD. A previously healthy 13-yr-old male presented with a diffusely swollen thyroid gland. Thyroid function tests revealed low total thyroxin and TBG concentrations, indicating a TBG deficiency. Ultrasonography revealed a mildly swollen thyroid gland with a nodule (14 × 12 × 19 mm) in the left lobe. Genetic analysis of peripheral blood revealed a previously reported variant, which resulted in complete loss of TBG function. The nodule was identified as a follicular adenoma using fine-needle aspiration. Subsequently, the adenoma shrank without treatment. This pubertal case suggests that careful observation with ultrasonography is warranted for follicular adenoma in patients with TBG deficiency and that treatment may not be required.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10825654 | PMC |
| http://dx.doi.org/10.1297/cpe.2023-0031 | DOI Listing |
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