Because of its properties, silver is among the most used metals both as salt and as nanomaterials (NMs), hence reaching the environment. Multigenerational (MG) exposure testing is scarce, and especially so for NMs and soil invertebrates. In this study the MG effects of Ag NMs (Ag NM300K) and Ag salt (AgNO) were assessed, using in LUFA 2.2 soil. Survival, reproduction and internal Ag concentration in the animals were measured throughout 7 generations (5 generations (F0-F4) in spiked soil plus 2 (F5-F6) in clean soil) exposed to sublethal concentrations corresponding to the reproduction EC and EC obtained in standard toxicity tests (45 and 60 mg Ag per kg soil DW for AgNO; 20 and 60 mg Ag per kg soil DW for Ag NM300K). MG exposure caused a dose-related decrease in reproduction for both Ag forms. Ag uptake peaked in the F1 (64 days) for AgNO and F2 (96 days) for Ag NM300K, after which it decreased. In agreement with toxicokinetic studies, a maximum body Ag concentration was reached (20 mg Ag per kg body DW (AgNO) and 70 mg Ag per kg body DW (Ag NM300K)) and after which detoxification mechanisms seem to be activated with elimination of Ag accompanied by a decrease in reproduction. Transfer to clean soil allowed Ag to be (fully) eliminated from the animals. This MG study confirmed the effects determined in standard reproduction toxicity tests but further allowed to monitor the dynamics between exposure and effects of the Ag materials, and how the animals seem to cope with Ag for 7 generations by compensating between detoxification and reproductive output.
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http://dx.doi.org/10.1039/d3na00487b | DOI Listing |
Int J Radiat Biol
December 2024
Biology and Environmental Chemistry Division, Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI), Chiba, Japan.
Purpose: Since the genotoxicity of ionizing radiation was demonstrated in the 1920s, its hereditary effects have remained a serious concern for human society. The International Commission on Radiological Protection has highlighted the need for appropriate protection against hereditary effects of radiation in humans. In this paper, we review the literature on the possible multigenerational and transgenerational effects following testicular exposure to radiation, focusing on sperm epigenetic alterations as possible mechanisms.
View Article and Find Full Text PDFAquat Toxicol
December 2024
Department of Biosciences, University of Milan, Via Celoria 26, 20133 Milan, Italy.
Although sediments are important reservoirs of plastics, most of the ecotoxicological studies on these contaminants are focused on the organisms living in the water column, while only a smaller number of evidence concerns the plastic impact on benthic species. Therefore, this study compared the multigenerational effects on the sediment-dwelling midge Chironomus riparius exposed to both virgin polystyrene microbeads (22,400-224,000 plastics/kg sediments dry weight), and plastic mixtures (40-420 plastics/kg dry weight) collected from four of the main tributaries of Po River (Ticino, Adda, Oglio and Mincio Rivers, Northern Italy) to evaluate the role played by other characteristics related to these physical contaminants in determining their toxicity as opposed to concentration alone. The modified Chironomid Life-Cycle Toxicity Test (OECD 233) was used to evaluate the multigenerational effects on the Emergence and Development Rates, Fecundity and Fertility.
View Article and Find Full Text PDFEnviron Epigenet
November 2024
Medical Genetics Laboratory, Centro Diagnostico Italiano, Milan, MI 20147, Italy.
Among the various environmental pollutants, dioxin, a highly toxic and widely used compound, is associated with numerous adverse health effects, including a potentially toxic multigenerational effect. Understanding the mechanisms by which dioxin exposure can affect sperm epigenetics is critical to comprehending the potential consequences for offspring health and development. This study investigates the possible association between weighted epimutations, hypothesized as markers of epigenetic drift, and dioxin exposure in sperm tissues.
View Article and Find Full Text PDFCurr Opin Rheumatol
December 2024
Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
Environ Pollut
December 2024
Marine College, Shandong University, Weihai, Shandong, 264209, China. Electronic address:
Triphenyltin (TPT), a widely used environmental contaminant in antifouling paints, is known for its neurotoxic effects. To investigate the multigenerational impacts of long-term exposure (6 weeks) to environmental concentrations of TPT (100 ng/L) on either parent, we performed mixed mating between control and exposed groups (males or females). Although there was no direct contact with TPT in the subsequent generations, both the first and second generations displayed behavioral abnormalities, including reduced activity and impaired cognitive function, with pronounced gender differences and anxiety-like behaviors.
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