Adult-onset immunodeficiency syndrome is characterized by the presence of anti-interferon-gamma (IFN-γ) autoantibody and the distribution of infections. Here, we describe bacteremia in a Thai woman who also had anti-IFN-γ autoantibody. The patient was also suffering from osteomyelitis and a peri-orbital abscess. Her symptoms were completely eradicated after surgical intervention and the administration of appropriate antibiotics.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10825596 | PMC |
| http://dx.doi.org/10.1016/j.idcr.2024.e01926 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Utility of F-Fluorodeoxyglucose Positron Emission Tomography in Evaluating Disseminated Nontuberculous Mycobacterial Infection in Patients With Anti-interferon-γ Autoantibodies.
Open Forum Infect Dis
December 2024
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Background: Managing disseminated nontuberculous mycobacterial (NTM) infection in patients with neutralizing anti-interferon-γ autoantibodies (AIGAs) poses substantial challenges due to the lack of established treatment guidance and predictive tools for clinical outcomes. In this study, we investigated the utility of F-fluorodeoxyglucose (2-[F]FDG) positron emission tomography (PET) in guiding treatment decisions, with a focus on its ability to predict rehospitalization outcomes.
Methods: We conducted a post hoc analysis of the first available 2-[F]FDG PET scans of patients with AIGAs and disseminated NTM infection from a prospective observational multicenter cohort.
[ infection complicated by talaromycosis in a patient with positive anti-interferon-γ autoantibodies: a case report].
Zhonghua Jie He He Hu Xi Za Zhi
December 2024
Department of Respiratory and Critical Care Medicine, Fuzhou Provincial Hospital Affiliated to Fuzhou University, Fuzhou350001, China.
Article Synopsis
- - High levels of antibodies to interferon-gamma (IFN-γ) are linked to infections from intracellular pathogens, especially non-tuberculous mycobacteria (NTM) and tuberculosis (MTB).
- - The case study discusses a non-immunosuppressed patient who had both MTB infection and complications from NTM, which led to a severe condition called secondary hemophagocytic syndrome.
- - The report emphasizes the importance of recognizing this uncommon combination of infections to prevent misdiagnosis or unnecessary treatments for patients.
Clinical and chest CT manifestations of Talaromycosis marneffei: a retrospective study comparing anti-IFN-γ autoantibodies-positive and HIV-positive cases.
BMC Infect Dis
November 2024
Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
Background: To explore the clinical and chest CT features of Talaromycosis marneffei (TSM), and to compare the differences between anti‑IFN‑γ autoantibodies‑positive and HIV-positive cases.
Methods: Clinical data and chest CT images of 54 HIV-negative patients with Talaromyces marneffei (TM) infection and positive anti-interferon-γ (anti-IFN-γ) autoantibody were retrospectively analyzed. Ninety-three HIV-positive patients with TM infection during the same period were included as controls.
Increased Inflammatory Responses in Patients With Active Disseminated Non-Tuberculous Mycobacterial Infection and High Anti-Interferon-Gamma Autoantibodies.
Immune Netw
October 2024
Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Article Synopsis
- Adult-onset immunodeficiency (AOID) is linked to anti-IFN-γ autoantibodies (auAbs), which may increase susceptibility to disseminated nontuberculous mycobacterial (dNTM) infections, alongside other molecular factors.
- A study involving dNTM patients assessed plasma anti-IFN-γ auAb levels through ELISA and whole-blood RNA sequencing, showing significantly higher auAb levels in active cases compared to inactive patients and healthy controls.
- The research found that active infection was marked by over-expressed inflammatory pathways, under-expressed type-2 immunity pathways, and elevated plasma IL-8 levels, suggesting IL-8 could potentially serve as a key mediator in
Anti-interferon gamma-inducible protein 16 antibodies: Identification of a novel autoantigen in idiopathic interstitial pneumonia and its clinical characteristics based on a multicenter cohort study.
Clin Immunol
November 2024
Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Autoantibodies are detected in idiopathic interstitial pneumonias (IIPs) without a clear connective tissue disease diagnosis, and their clinical significance is unclear. This study aimed to identify a novel autoantibody in IIPs. We screened 295 IIP patients using a S-methionine labeled protein immunoprecipitation assay.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!