AI Article Synopsis

  • The study explored the oral microbiota of patients with Papillon-Lefèvre syndrome and compared it to their family members and individuals with chronic periodontitis.
  • The analysis showed that patients had a microbiome dominated by Aggregatibacter actinomycetemcomitans, a known periodontopathogen, while their healthy family members had a microbiome similar to those with mild periodontitis.
  • The findings suggest that targeting A. actinomycetemcomitans could lead to improved oral health for individuals with this syndrome.

Article Abstract

Aims: The oral microbiota composition of patients diagnosed with Papillon-Lefèvre-syndrome and treated for several years were compared to those existing in the oral cavity of the clinically healthy family members and a cohort of patients having various stages of chronic periodontitis.

Materials And Methods: A family with two sisters affected with severe periodontitis and with the typical skin symptoms of Papillon-Lefèvre-syndrome, and symptomless parents and third sibling were investigated. The Patients received periodontal treatment for several years and their oral microbiome was analysed by amplicon sequencing. Data were evaluated by microbial cluster analysis.

Results: The microbiome of the patients with Papillon-Lefèvre-syndrome was predominated with Aggregatibacter actinomycetemcomitans and associated oral periodontopathogens. Although the clinically healthy family members showed no oral disorder, their microbiome resembled that of subjects having mild periodontitis.

Conclusions: Predominance of A. actinomycetemcomitans in the subgingival microbiome of patients with Papillon-Lefèvre-syndrome suggests that specific treatment strategies directed against this pathobiont may improve the oral health status of the affected individuals.

Trial Registration: The study was conducted in accordance with the Declaration of Helsinki and the ethical permission has been issued by the Human Investigation Review Board of the University of Szeged, Albert Szent-Györgyi Clinical Centre (Permission No. 63/2017-SZTE). September 19, 2017.  https://u-szeged.hu/klinikaikutatas/rkeb-altal-jovahagyott/rkeb-2017 .

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10832247PMC
http://dx.doi.org/10.1186/s12903-024-03856-zDOI Listing

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