Our study aims to determine the association between obesity and meniscal tears involving the posterior third of the medial meniscus and meniscal root tears. We conducted a 3-year retrospective review of isolated operatively treated meniscal injuries in adult patients performed by a single surgeon. Cases with concomitant pathology were excluded. Patient demographics, height, weight, and body mass index (BMI) were recorded and compared against location of meniscus tear noted via magnetic resonance imaging and arthroscopic imaging. Eighty-nine patients met the inclusion criteria, of which 65.2% were obese (BMI > 30) and 10.1% were morbidly obese (BMI > 40). Average BMI across all patients was 32.6 ± 6.7. Forty-four patients had a tear involving the posterior horn of the medial meniscus, including 20 involving the meniscal root. The average BMI of patients with tears involving the meniscal root was 35.7 ± 6. There was a statistically significant association between type of meniscus tear and BMI as well as height. Obese patients were more likely to have a posterior horn of the medial meniscus tear (odds ratio [OR]: 1.59) and meniscal root tear (OR: 124.67), as were morbidly obese patients (OR: 2.21 and 5.41, respectively). Elevated BMI is associated with posterior horn of the medial meniscus tear. Obesity and morbid obesity are strongly associated with meniscal root tears and tears included in the posterior third of the medial meniscus.
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http://dx.doi.org/10.1055/s-0044-1779512 | DOI Listing |
J Orthop Sci
January 2025
Department of Orthopedic Surgery, Graduate School of Medical Science Kanazawa University, 13-1 Takara-machi, Kanazawa-city, 920-8641, Japan.
Background: Evaluating the correlation between degenerative meniscus tears and medial meniscus extrusion is necessary to determine the appropriate treatment plan for early-stage knee osteoarthritis. This study evaluated the relationship between degenerative meniscal tears and medial meniscus extrusion in early-stage knee osteoarthritis by using ultrasonography.
Methods: A total of 132 knees from 123 patients with early-stage knee osteoarthritis were evaluated retrospectively.
Orthop J Sports Med
January 2025
Department of Orthopaedic Surgery, Case Western Reserve University, Cleveland, Ohio, USA.
Background: Previous studies have demonstrated that lateral meniscal allograft transplantation (MAT) through medial arthrotomy showed less extrusion than that of the lateral arthrotomy. However, there is a paucity of literature reporting clinical and radiological outcomes after lateral MAT through the medial arthrotomy.
Hypothesis: Lateral MAT through a medial arthrotomy would show significantly improved clinical scores and minimal joint space narrowing compared with preoperative status.
PLoS One
January 2025
Faculty of Medicine Dentistry and Health Sciences, Department of Medicine, Royal Melbourne Hospital, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia.
Objectives: We previously reported that CCL17 gene-deficient mice are protected from developing pain-like behaviour and exhibit less disease in destabilization of medial meniscus (DMM)-induced OA, as well as in high-fat diet (HFD)-exacerbated DMM-induced OA. Here, we explored if therapeutic neutralization of CCL17, using increasing doses of a neutralizing monoclonal antibody (mAb), would lead to a dose-dependent benefit in these two models.
Design: DMM-induced OA was initiated in male mice either fed with a control diet (7% fat) or 8 weeks of a 60% HFD, followed by therapeutic intraperitoneal administration (i.
J Nanobiotechnology
January 2025
State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, People's Republic of China.
RNA interference (RNAi) and oxidative stress inhibition therapeutic strategies have been extensively utilized in the treatment of osteoarthritis (OA), the most prevalent degenerative joint disease. However, the synergistic effects of these approaches on attenuating OA progression remain largely unexplored. In this study, matrix metalloproteinase-13 siRNA (siMMP-13) was incorporated onto polyethylenimine (PEI)-polyethylene glycol (PEG) modified FeO nanoparticles, forming a nucleic acid nanocarrier termed si-Fe NPs.
View Article and Find Full Text PDFOsteoarthr Cartil Open
March 2025
Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Objective: Osteoarthritis is a chronic, debilitating disease that causes long-term pain and immobility. Germline deletion of Phlpp1 or administration of small molecules that inhibit Phlpp1 prevents post-traumatic osteoarthritis (PTOA) in mice. However, the chondrocyte-intrinsic role of Phlpp1 in PTOA progression is unknown.
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