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Harmonizing the forensic nomenclature for STR loci D6S474 and DYS612. | LitMetric

AI Article Synopsis

  • The autosomal STR D6S474 and Y-chromosomal STR DYS612 have inconsistencies in their reported repeat structures and allele lengths in forensic literature.
  • * These discrepancies arise when comparing commercial assay results with older allele frequency data or multiple assays using reference materials.
  • * The authors review this literature and suggest improvements for how each STR should be treated in future forensic applications.

Article Abstract

The autosomal STR D6S474 and the Y-chromosomal STR DYS612 have been reported in multiple ways in the forensic literature, with differences in both the bracketed repeat structures and counting of numerical length-based capillary electrophoresis (CE) alleles. These issues often come to light when STR loci are introduced in commercial assays and results compared with historical publications of allele frequency data, or multiple assays are characterized with reference materials. We review the forensic literature and other relevant information, and provide suggestions for the future treatment of each STR.

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Source
http://dx.doi.org/10.1016/j.fsigen.2024.103012DOI Listing

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