The first synthesis of macrocyclic α-ABpeptoids with varying lengths is described. X-ray crystal structures reveal that cyclic trimer displays a chair-like conformation with a amide sequence and cyclic tetramer has a saddle-like structure with an uncommon amide arrangement. The creation of a DNA-encoded combinatorial library of macrocyclic α-ABpeptoids is described.
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| http://dx.doi.org/10.1021/acs.orglett.3c04387 | DOI Listing |
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