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Prevalence and characteristics of participants in 2024: findings from a general population survey in France.
Front Public Health
December 2024
Service Universitaire d'Addictologie de Lyon (SUAL), Le Vinatier Psychiatrie Universitaire Lyon Métropole, Bron, France.
Background: Dry January is a one-month alcohol abstinence challenge for the general population running since 2013 in the United Kingdom, and 2020 in France. Dry January has gained increasing popularity among the public, but studies assessing the individual characteristics associated with awareness and participation remain sparse.
Methods: Using quota sampling, a representative sample of 5,000 French adults completed an online cross-sectional survey between 8 and 17th January 2024.
[Epigenetic changes in alcohol addiction and therapeutic perspectives].
Ann Pharm Fr
January 2025
Inserm UMR1247, groupe de recherche sur l'alcool et les pharmacodépendances, centre universitaire de recherche en santé, université Picardie Jules-Verne, chemin du Thil, Amiens, France. Electronic address:
Alcohol consumption is a major public health issue. Patients with Alcohol Use Disorder (AUD) can benefit from five treatments that preferentially target membrane receptors, and whose efficacy is generally modest. However, a large body of experimental evidence points to an important role for epigenetics in the effects of alcohol consumption, and epidrugs that modify the epigenome offer an interesting alternative to current therapeutic options.
View Article and Find Full Text PDFShould the French approval of baclofen for alcohol dependence be extended to abstinence maintenance?
Encephale
September 2024
Unité Inserm UMRS 1247, université de Picardie Jules-Verne, Amiens, France.
Ever since 2018 France has been the only country to approve the gamma aminobutyric acid type B (GABA-B) receptor agonist baclofen for alcohol dependence. This authorization follows a ten-year period of intensive off-label use during which baclofen was used in doses of up to 300 and even 400mg per day to support the gradual reduction of alcohol consumption in patients suffering from alcohol dependence. However, in international clinical trials, baclofen has mainly been studied to support the maintenance of abstinence.
View Article and Find Full Text PDFAlcohol Rehabilitation Within 3 Months After Alcohol Hepatitis and Survival - A National Analysis.
Clin Gastroenterol Hepatol
August 2024
AP-HP.Centre, Groupe Hospitalier Cochin Port Royal, DMU Cancérologie et Spécialités Médico-Chirurgicales, Service de Maladies du Foie, Paris, France; Université Paris Cité, Paris, France. Electronic address:
Background & Aims: There is limited understanding of the benefits of alcohol rehabilitation after alcohol hepatitis (AH).
Methods: We conducted a 2012 to 2021 national longitudinal study involving adult inpatients diagnosed with AH in France. We assessed the primary outcome of liver transplantation or death within 1 year after AH, including in its complicated form (CAH) defined as ≥2 hepatic or extrahepatic complications within 4 weeks after AH.
Predictive factors of cognitive impairment in alcohol use disorder inpatients.
Addict Behav
November 2024
UFR de Médecine, Université Paris Cité, 85 boulevard Saint-Germain, 75006 Paris, France; Département de psychiatrie et d'addictologie, AP-HP, DMU Neurosciences, Hôpital Bichat - Claude Bernard, APHP GHU Nord, 46 rue Henri Huchard, 75018 Paris, France; Centre ChronoS, GHU Paris - Psychiatry & Neurosciences, 1 rue Cabanis, 75014 Paris, France; CNRS UPR 3212, Institute for Cellular and Integrative Neurosciences, Strasbourg, France.
Background: Cognitive impairments are common in patients with AUD and worsen the prognosis of addiction management. There are no clear guidelines for screening cognitive impairments in hospitalized patients with AUD.
Methods: Fifty-seven patients with an AUD history who were admitted to an acute hospital and assessed by the addiction care team were included.
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