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Diagnostic and Therapeutic Insights Into Pediatric Neurosarcoidosis: Observations From French Pediatric Rheumatology Centers.
Pediatr Neurol
January 2025
Department of General Pediatrics, Pediatric Internal Medicine, Rheumatology and Infectious Diseases, National Reference Centre for Rare Pediatric Inflammatory Rheumatisms and Systemic Autoimmune Diseases (RAISE), Robert-Debré University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Paris Cité, INSERM, Centre de Recherche sur l'inflammation UMR 1149, Paris, France. Electronic address:
Article Synopsis
- - The study reviewed 11 pediatric patients diagnosed with neurosarcoidosis (NS), predominantly affecting girls, with an average diagnosis age of around 10 to 11.5 years, highlighting typical neurological symptoms such as headaches and eye involvement.
- - Most patients experienced meningitis and were treated primarily with corticosteroids and TNF-alpha inhibitors, with eight out of 11 requiring biologic therapies to achieve remission.
- - The findings emphasize the importance of recognizing the clinical features of pediatric NS and suggest that early intervention with TNF-alpha biologics can lead to better management outcomes for these children.
Sarcoidosis Mortality in North Carolina: Role of Region, Race, and Other Sociodemographic Variables.
N C Med J
June 2024
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Brody School of Medicine, East Carolina University.
Background: There is regional variability in sarcoidosis mortality across the United States. North Carolina ranks highly in sarcoidosis-related mortality, especially among African Americans (AA). We sought to determine any regional variability of sarcoidosis-related mortality and the relationship to sociodemographic determinants of health in North Carolina.
View Article and Find Full Text PDFPrevalence of sarcoidosis in Colombia: An analysis of the Ministry of Health databases.
Public Health
December 2024
Department of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogota, Colombia.
Article Synopsis
- Sarcoidosis prevalence varies globally, and a study in Colombia aimed to estimate its prevalence using health service data collected from January 2018 to December 2022.
- The research utilized a cross-sectional design and analyzed 6,828 consultation records from the Comprehensive System of Social Protection Information (SISPRO) focusing on relevant ICD-10 codes.
- The findings revealed a sarcoidosis prevalence of 12.8 cases per 100,000 inhabitants, predominantly affecting women and peaking in the age group of 60-69 years, emphasizing the need for ongoing monitoring and improved treatment strategies.
Clinicopathological analysis of nasopharyngeal tuberculosis.
Ann Med
December 2024
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Background: The aim of this study is to examine the clinical and pathological attributes of nasopharyngeal tuberculosis.
Methods: We conducted a retrospective analysis of the clinicopathologic characteristics of nasopharyngeal tuberculosis in 14 patients. The medical records and imaging data obtained between March 2004 and February 2023 were scrutinized.
Excess of severe autoimmune diseases in women with premature ovarian insufficiency: a population-based study.
Hum Reprod
November 2024
Department of Obstetrics and Gynecology, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Pohde, Oulu, Finland.
Article Synopsis
- Research shows that women with premature ovarian insufficiency (POI) are significantly more likely to have a history of severe autoimmune diseases, occurring 2.6 times more often than those without POI.
- The study analyzed data from nearly 4,000 women diagnosed with spontaneous POI, comparing their health outcomes to over 15,000 matched controls, which included tracking autoimmune diagnoses from childhood through 2017.
- Findings indicate that women with POI not only had a higher prevalence of autoimmune disorders prior to their diagnosis but also faced a 2 to 3 times increased risk for these diseases for several years afterward.
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