Exploring new imines as anti-inflammatory COX and 5-LOX inhibitors with an improved pharmacokinetic profile.

Dual COX/5-LOX inhibition is a bright strategy for developing new potent and safe anti-inflammatory agents. New imines were synthesized and evaluated for their anti-inflammatory activity. The most active compounds were further investigated for their safety profile. Their molecular docking and physicochemical parameters were assessed. A new LC-MS/MS method was developed for the quantification of compound in rat plasma. Synthesized compounds were found to have anti-inflammatory activity (77-88% edema inhibition). In addition, , and showed analgesic activity (92.50, 95.71 and 96.28% protection, respectively). showed dual COX-2/5-LOX activity. Molecular docking expected the binding pattern of compounds in COX-1, COX-2 and 5-LOX active sites. The pharmacokinetic parameters of compound were also obtained.