AI Article Synopsis
- * Blood flow shear stress influences gene expression in endothelial cells, affecting inflammation, thrombosis, oxidative stress, and cell permeability, with some mechanosensitive genes identified as key players.
- * The article reviews these mechanosensitive genes and their pathways, highlighting recent research and potential new therapeutic targets for treating atherosclerosis.
Article Abstract
Atherosclerotic cardiovascular disease and its complications are a high-incidence disease worldwide. Numerous studies have shown that blood flow shear has a huge impact on the function of vascular endothelial cells, and it plays an important role in gene regulation of pro-inflammatory, pro-thrombotic, pro-oxidative stress, and cell permeability. Many important endothelial cell mechanosensitive genes have been discovered, including , gene family, , , , , , , , , , , and . Some of them have been intensively studied, whereas the relevant regulatory mechanism of other genes remains unclear. Focusing on these mechanosensitive genes will provide new strategies for therapeutic intervention in atherosclerotic vascular disease. Thus, this article reviews the mechanosensitive genes affecting vascular endothelial cells, including classical pathways and some newly screened genes, and summarizes the latest research progress on their roles in the pathogenesis of atherosclerosis to reveal effective therapeutic targets of drugs and provide new insights for anti-atherosclerosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10825297 | PMC |
| http://dx.doi.org/10.1016/j.gendis.2023.06.016 | DOI Listing |
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