AI Article Synopsis
- Atrophic kidney-like lesion (AKLL) is a rare kidney tumor recently recognized as a provisional entity by the Genitourinary Pathology Society, with only 16 cases documented so far.
- A new case is reported that shares similar characteristics with previously identified AKLLs, featuring unique immunohistochemical staining patterns.
- The histomorphologic traits of AKLL can resemble other kidney conditions, making accurate diagnosis challenging; thus, understanding its distinguishing features is crucial for correct evaluation.
Article Abstract
Atrophic kidney-like lesion (AKLL) is a rare kidney lesion, which was recently suggested by the Genitourinary Pathology Society as a provisional entity. As of now, 16 examples of AKLL have been described in the literature. Here we report a new tumor which shows similar clinicopathologic characteristics with those previously reported in AKLL. Immunohistochemical (IHC) studies in the current lesion identified a biphasic staining pattern consisting of a mixture of WT1+/KRT7-/PAX8- large dilated cysts and WT-/KRT7+/PAX8+ small atrophic cysts. Histomorphologic features of AKLL overlap with several neoplastic and non-neoplastic entities which can lead to mischaracterization. Awareness of the differentiating features is likely important when evaluating these lesions.
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| http://dx.doi.org/10.1177/10668969241226703 | DOI Listing |
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