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Impact of sodium-glucose cotransporter inhibitors in acute coronary syndrome patients on endothelial function and atherosclerosis related-biomarkers: ATH-SGLT2i pilot study.
Medicine (Baltimore)
November 2024
Department of Cardiology, Rabta Teaching Hospital, University of Medicine Tunis, Tunis, Tunisia.
Little is known about the effects of sodium-glucose co-transporter 2 inhibitors (SGLT2i) on atherosclerosis. We aimed to determine if a 90-day intake of Dapagliflozin could improve atherosclerosis biomarkers (namely endothelial function assessed by flow-mediated dilatation [FMD] and carotid intima-media thickness [CIMT]) in diabetic and non-diabetic acute coronary syndrome (ACS) patients when initiated in the early in-hospital phase. ATH-SGLT2i was a prospective, single-center, observational trial that included 113 SGLT2i naive patients who were admitted for ACS and who were prescribed Dapagliflozin at a fixed dose of 10 mg during their hospital stay for either type 2 diabetes or for heart failure.
View Article and Find Full Text PDFObserving Changes in Motoneuron Characteristics Following Distorted Sensorimotor Input via Blood Flow Restriction.
J Appl Physiol (1985)
January 2025
Department of Electrical Engineering and Automation, Aalto University, Espoo, Finland.
Disruption of the blood supply to a limb in conjunction with active movement boosts muscle growth, aids in rehabilitation, and allows controlled exploration of the sensorimotor system. Yet, the underlying neuromechanical changes have not been observed in great detail. This study aims to report the acute neuromuscular effects of temporary blood flow restriction (BFR) through behavioral changes at the level of motor units (MUs) using high-density surface electromyography on the abductor digiti minimi muscle during 20 trapezoidal and sinusoidal isometric force tracking tasks (5 pre-BFR, 5 during BFR, and 10 post-BFR).
View Article and Find Full Text PDFDevelopment of a novel laboratory approach for evaluating the adhesion strength of biofilms to human dentine.
Int Endod J
January 2025
School of Medicine and Dentistry, Griffith University, Gold Coast, Australia.
Introduction: Biofilms may show varying adherence strengths to dentine. This study quantified the shear force required for the detachment of multispecies biofilm from the dentine using fluid dynamic gauging (FDG) and computation fluid dynamics (CFD). To date this force has not been quantified.
View Article and Find Full Text PDFPorous Silicon on Paper: A Platform for Quantitative Rapid Diagnostic Tests.
ACS Appl Mater Interfaces
January 2025
Interdisciplinary Material Science Program, Vanderbilt University, Nashville, Tennessee 37235, United States.
Porous silicon (PSi) thin films on silicon substrates have been extensively investigated in the context of biosensing applications, particularly for achieving label-free optical detection of a wide range of analytes. However, mass transport challenges have made it difficult for these biosensors to achieve rapid response times and low detection limits. In this work, we introduce an approach for improving the efficiency of molecule transport in PSi by using open-ended PSi membranes atop paper substrates in a flow-through sensor scheme.
View Article and Find Full Text PDFBiofloc technology significantly reshapes water microbiome and improves survival rates in Japanese eel ().
Microbiol Spectr
January 2025
Department of Biology and Chemistry, Changwon National University, Changwon, South Korea.
Unlabelled: Global aquaculture production faces the challenge of biologically cycling nitrogenous waste. Biofloc technology (BFT) systems offer the potential to reduce water consumption and eliminate waste products by using beneficial microorganisms to convert waste into usable nutrients or non-toxic molecules. Unlike flow-through systems (FTS), which depend on continuous water exchange and result in higher operational costs as well as limited microbiome stability, BFT operates without the need for constant water exchange.
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