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Robert Wartenberg and the Hallervorden Affair, 1953: A Clash Between Medical Ethics and Cold War Politics.
Neurology
January 2025
Department of Neurology, Henry Ford Health, Detroit, MI; and.
Robert Wartenberg was an emigrant from Nazi Germany and an iconic pioneer in neurology, describing eponyms and helping to found and nurture the American Academy of Neurology. However, in 1953, ironically, he became embroiled in a controversial event regarding the German neuroscientist and Nazi collaborator Julius Hallervorden. Wartenberg attempted to convince the Dutch delegation to attend the International Neurological Congress in Lisbon from which they had withdrawn in response to Hallervorden's inclusion as a speaker.
View Article and Find Full Text PDFPolitics, policy and action: lessons from rural GP advocacy in Ireland.
Rural Remote Health
November 2024
School of Medicine, University of Limerick, Limerick, Ireland.
Context: Ireland has one of the most rural populations in Europe. Rurality presents challenges when accessing health services but should not be perceived as problematic and in need of a structural fix. Structural urbanism where health care is viewed as a commodity for individuals, rather than an infrastructure for populations, innately favours larger urban populations and has detrimental outcomes for rural health.
View Article and Find Full Text PDFUnique Lessons From the Natural Progression of Rejection in Human Uterine Allografts.
Clin Transplant
August 2024
Division of Abdominal Transplantation, Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, Texas, USA.
Introduction: Uterus transplantation (UTx) is a novel treatment for absolute uterine infertility. Acute T cell-mediated rejection (TCMR) can be monitored only through serial cervical biopsies.
Methods: This study, the first of its kind in human transplantation, evaluated clinical, serological, and pathophysiological manifestations of allograft rejection from immunosuppression withdrawal (ISW) to graft hysterectomy (Hx).
Regulatory histories of recently withdrawn ovarian cancer treatment indications of 3 PARP inhibitors in the US and Europe: lessons for the accelerated approval pathway.
J Pharm Policy Pract
June 2024
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Background: Withdrawals of drug indications may reveal potential inadequacies in the regulatory approval processes of new drugs. Understanding potential weaknesses of the regulatory approval process is paramount given the increasing use of expedited pathways. In this paper, we focus on three poly-ADP-ribose polymerase inhibitors (olaparib, rucaparib and niraparib) for the treatment of women with heavily pretreated, recurrent ovarian cancer, which were eventually withdrawn.
View Article and Find Full Text PDFStudy protocol: A randomized, double-blind, placebo-controlled trial of isavuconazole prophylaxis for the prevention of covid-19-associated pulmonary aspergillosis.
Contemp Clin Trials Commun
June 2024
University of California Davis Center for Valley Fever, Sacramento, CA, USA.
Background: During the early stages of the coronavirus disease 2019 (COVID-19) pandemic, those with severe COVID-19 infection were at risk for a number of opportunistic infections including COVID-19-associated pulmonary aspergillosis (CAPA). We initiated a randomized clinical trial to evaluate whether isavuconazole, a triazole antifungal, could prevent CAPA and improve survival in patients admitted to the ICU with severe COVID-19 infection.
Methods: We designed a phase III/IV randomized, double-blind, two-arm, placebo-controlled trial evaluating standard of care (SOC) plus isavuconazole versus SOC plus placebo and were to enroll participants admitted to the ICU with severe COVID-19 infection at three medical centers in California, United States.
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