Pilonidal sinus disease (PSD) is a common condition that typically affects young adults. PSD may cause significant morbidity due to its chronic nature and tendency to recur. Laser ablation has recently shown promising results in the treatment of PSD, but comparative studies are sparse. We aimed to compare laser ablation with two conventional treatment options: simple excision with direct closure and excision with flap reconstruction. This retrospective study material included patients who underwent PSD surgery in the plastic surgery department of a single academic teaching hospital. Patients were divided into three groups based on the operation technique: laser group, direct closure group, and flap group. Preoperative and postoperative data were compared between the groups including patient characteristics, residual disease, recurrent disease, complications, and re-operations. Among the 278 patients, 66 underwent laser treatment, 134 excision with direct closure, and 78 excision with flap closure. The follow-up time ranged from 15.4 ± 7.6 months in the laser group to 87.6 ± 29.3 months in the flap group. Eventless healing occurred in 67.7% of the patients in the laser group, 66.4% of the patients in the direct closure group, and 56.4% of the patients in the flap group. There was significantly more residual disease in the laser group whereas significantly more complications were found in the direct closure and flap groups. The advantages of laser treatment include fast postoperative recovery and reduced risk of complications.
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http://dx.doi.org/10.1007/s10103-024-03993-5 | DOI Listing |
BMC Oral Health
January 2025
Basic Dental Sciences Department, Faculty of Dentistry, Zarqa University, PO Box 2000, Zarqa, 13110, Jordan.
Objective: This study aimed to investigate and compare the histological response of rabbit dental pulp after direct pulp capping with 3 different materials: mineral trioxide aggregate (MTA), nanoparticles of fluorapatite (Nano-FA), and nanoparticles of hydroxyapatite (Nano-HA) after 4 and 6-week time intervals.
Material And Methods: A total of 72 upper and lower incisor teeth from 18 rabbits were randomly categorized into 3 groups)24 incisors from six rabbits each. MTA Group: teeth were capped with MTA.
J Craniofac Surg
January 2025
Hunan Provincial Key Laboratory of TCM Diagnostics, Institute of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan, People's Republic of China.
Dural closure is a crucial step in cranial surgery, essential for preventing complications like cerebrospinal fluid leakage, wound infections, and meningitis. Traditional suturing techniques, however, pose challenges such as technical difficulty and the potential for tissue damage. This retrospective study aimed to assess the safety and effectiveness of a nonsuture dural closure method using medical glue for direct adhesion of a patch to the dura mater.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
University of Bonn: Rheinische Friedrich-Wilhelms-Universitat Bonn, Kekulé Institute for Organic Chemistry and Biochemistry, Gerhard-Domagk-Straße 1, 53121, Bonn, GERMANY.
Taxa-4,11-diene is made by the taxa-4,11-diene synthase (TxS) from Taxus brevifolia. The unique reactivity of the taxane system is characterised by long distance hydrogen migrations in the biosynthesis. This study demonstrates that selective long range hydrogen migrations also play a role in the high energy process of the EI-MS fragmentation of taxa-4,11-diene.
View Article and Find Full Text PDFBMC Pharmacol Toxicol
January 2025
Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
The main objective of this study was to investigate the optimal post-left atrial appendage closure (LAAC) anticoagulation strategy, focusing on minimizing device-related thrombosis (DRT) and thromboembolism (TE) events without increasing bleeding risk. After successful LAAC, consecutive participants were treated with 45-day anticoagulants (rivaroxaban 15 mg daily, dabigatran 110 mg twice a day, and warfarin). The efficacy endpoints included DRT, TE, and hospital readmissions due to cardiac caused, while safety endpoints encompassed bleeding events, monitored over a 12-month follow-up period.
View Article and Find Full Text PDFSci Rep
January 2025
School of Geosciences, Yangtze University, Wuhan, 430100, Hubei, China.
As many oil and gas reservoirs approach depletion stages in the future, alongside growing energy storage demands, constructing gas storage facilities becomes critical for ensuring a stable natural gas supply. Consequently, a comprehensive geological analysis is essential to evaluate the feasibility of converting depleted gas reservoirs into gas storage facilities. The W gas reservoir in the Sichuan Basin, China, is nearing depletion and presents potential for conversion into a gas storage facility.
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