AI Article Synopsis
- Cells use mechanosensors on their surface and inside to detect physical and geometric signals from their environment, particularly through mechanosensitive ion channels (MICs).
- The nucleus acts not only as a protector of genetic material but also as a sensor that responds to physical features in tissue, influencing how cells migrate.
- The review emphasizes the complex interactions between nuclear transport and ion transport during cell migration, highlighting the need to understand how these mechanisms work together for better insights into cell movement in various conditions.
Article Abstract
Cell surface and intracellular mechanosensors enable cells to perceive different geometric, topographical, and physical cues. Mechanosensitive ion channels (MICs) localized at the cell surface and on the nuclear envelope (NE) are among the first to sense and transduce these signals. Beyond compartmentalizing the genome of the cell and its transcription, the nucleus also serves as a mechanical gauge of different physical and topographical features of the tissue microenvironment. In this review, we delve into the intricate mechanisms by which the nucleus and different ion channels regulate cell migration in confinement. We review evidence suggesting an interplay between macromolecular nuclear-cytoplasmic transport (NCT) and ionic transport across the cell membrane during confined migration. We also discuss the roles of the nucleus and ion channel-mediated mechanosensation, whether acting independently or in tandem, in orchestrating migratory mechanoresponses. Understanding nuclear and ion channel sensing, and their crosstalk, is critical to advancing our knowledge of cell migration in health and disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284253 | PMC |
| http://dx.doi.org/10.1016/j.tcb.2024.01.001 | DOI Listing |
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