Despite garnering considerable attention in recent years, the opioid epidemic in the United States has remained a challenge. Oral healthcare practitioners have been urged to take a leadership role in the face of this epidemic and consider carrying naloxone in dental offices. The US Food and Drug Administration recently deregulated naloxone 4-mg nasal spray to nonprescription status to increase its availability and access. This article, therefore, is intended to serve as a primer for dentists on the history, pharmacology, appropriate use, and administration of this critical, potentially lifesaving medication.
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