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Value of ctDNA in surveillance of adjuvant chemosensitivity and regimen adjustment in stage III colon cancer: a protocol for phase II multicentre randomised controlled trial (REVISE trial).
BMJ Open
January 2025
Colorectal Cancer Center, Department of General Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Introduction: The standard of care for stage III colon cancer is 3 or 6 months of double-drug regimen chemotherapy following radical surgery. However, patients with positive circulating tumour DNA (ctDNA) exhibit a high risk of recurrence risk even if they receive standard adjuvant chemotherapy. The potential benefit of intensified adjuvant chemotherapy, oxaliplatin, irinotecan, leucovorin and fluoropyrimidine (FOLFOXIRI), for ctDNA-positive patients remains to be elucidated.
View Article and Find Full Text PDFWhat makes an epidemic a disaster: the future of epidemics within the EM-DAT International Disaster Database.
BMC Public Health
January 2025
Centre for Research On the Epidemiology of Disasters (CRED), Institute of Health and Society (IRSS), UCLouvain, 1200, Woluwe-Saint-Lambert, Belgium.
Background: Reporting on and monitoring epidemics is a public health priority. Several initiatives and platforms provide epidemiological data, such as the EM-DAT International Disaster Database, which has 1525 epidemics and their impact reported since 1900, including 892 epidemics between 2000 and 2023. However, EM-DAT has inconsistent coverage and deficiencies regarding the systematic monitoring of epidemics data due to the lack of a standardized methodology to define what will be included under an epidemic disaster.
View Article and Find Full Text PDFThe function of SnRK1 in regulating darkness-induced leaf senescence in cucumber.
Plant Physiol Biochem
December 2024
College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang, 110866, China; Key Laboratory of Fruit and Vegetable Biology and Germplasm Enhancement, Shenyang Agricultural University, Shenyang, 110866, China; Key Laboratory of Protected Horticulture of Ministry of Education, Shenyang Agricultural University, Shenyang, 110866, China. Electronic address:
SnRK1 (SNF1-related kinase 1), a member of the SNF1 protein kinase superfamily, has been demonstrated to play a role in plant growth and development, as well as in stress responses. In this experiment, the leaf senescence of 'Xintaimici' cucumber was simulated by dark treatment and studied using SnRK1 activator/inhibitor and transient transformation technology. The effects of SnRK1 on cucumber leaf senescence, reactive oxygen species (ROS) metabolism, chloroplast structure, and photosynthetic characteristics were studied.
View Article and Find Full Text PDFPerovskite retinomorphic image sensor for embodied intelligent vision.
Sci Adv
January 2025
Department of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Retinomorphic systems that can see, recognize, and respond to real-time environmental information will extend the complexity and range of tasks that an exoskeleton robot can perform to better assist physically disabled people. However, the lack of ultrasensitive, reconfigurable, and large-scale integratable retinomorphic devices and advanced edge-processing algorithms makes it difficult to realize retinomorphic hardware. Here, we report the retinomorphic hardware prototype with a 4096-pixel perovskite image sensor array as core module to endow embodied intelligent vision functionalities.
View Article and Find Full Text PDFThe survey of vaccination hesitancy among the residents in Jinan.
PLoS One
January 2025
The Department of Disease Control and Prevention, Shandong Armed Police Forces General Hospital, Jinan, China.
Introduction: Vaccination is an important way to prevent disease, but vaccine hesitancy will impact vaccine coverage and indirectly affect health. This study aims to survey the status of vaccine hesitancy among adults in Jinan.
Methods: A cross-sectional study was conducted using the vaccine hesitancy scale among the parents of children and teenagers at hospitals in Jinan, China.
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