AI Article Synopsis
- Recent advancements in targeted drug delivery systems using nanoparticles (NPs) show promise for improving cancer treatment by enhancing drug efficacy and reducing side effects.
- The study focused on synthesizing resveratrol-loaded magnetic niosomes (RSV-MNIONPs) to assess their effectiveness in killing pancreatic cancer cells (Capan-1), with successful characterization and cytotoxicity testing performed.
- Results indicated that RSV-MNIONPs, especially with an external magnetic field, enhanced drug uptake and showed significant changes in cancer-related gene expression, highlighting their potential as an effective cancer therapy carrier.
Article Abstract
Recently, the presence of different nanoparticles (NPs) has developed targeting drug delivery in treatment of cancer cell. Targeted drug delivery systems using NPs have shown great promise in improving the efficacy of intracellular uptake as well as local concentration of therapeutics with minimizing side effects. The current study planned to synthesized resveratrol-loaded magnetic niosomes nanoparticles (RSV-MNIONPs) and evaluate their cytotoxicity activity in pancreatic cancer cells. For this aim, magnetic nanoparticles (MNPs) were synthesized and loaded into niosomes (NIOs) by the thin film hydration technique and then characterized via DLS, FT-IR, TEM, SEM and VSM techniques. Moreover, the cytotoxic activity of the RSV-MNIONPs on the Capan-1 cells line was assessed by the MTT test. The distribution number of RSV-MNIONPs was gained about 80 nm and 95 nm with surface charge of - 14.0 mV by SEM and TEM analysis, respectively. RSV loading efficacy in NIOs was about 85%, and the drug releases pattern displayed a sustained discharge with a maximum amount about 35% and 40%, within 4 h in pH = 7.4 and pH = 5.8, respectively. The cytotoxicity of the RSV-MNIONPs in the presence of an external magnetic field is higher than that of the RSV, indicating enhanced cellular uptake in their encapsulated states. Furthermore, RSV loaded MNNPs were found to induce more cell cycle arrest at the G0/G1 checkpoint than free RSV. Compared with RSV-treated cells, the mRNA expression levels of BAX, Bcl2, FAS, P 53, Cyclin D and hTERT, were significantly changed in cells treated with RSV loaded MNNPs. The niosomes NPs approaches have been widely used to attain higher solubility, improved bioavailability, enhanced stability, and control delivery of RSV. Our formulation displayed antitumor activity and can be considered an appropriate carrier with a great potential for future usage in cancer therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826113 | PMC |
| http://dx.doi.org/10.1186/s12935-024-03219-2 | DOI Listing |
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